Results 101 to 110 of about 243,283 (319)

Within-session chasing of losses and wins in an online eCasino

open access: yesScientific Reports
Chasing refers to the escalation of betting behaviour. It is conventionally seen when losing but can also be seen after wins. Diagnostic and screening items for gambling problems describe chasing as returning ‘another day’ to gamble.
Ke Zhang   +4 more
doaj   +1 more source

The specification of cross exchange rate equations used to test Purchasing Power Parity [PDF]

open access: yes, 2004
The Article considers the speciÞcation of models used to test Pur- chasing Power Parity when applied to cross exchange rates. SpeciÞcally, conventional dynamic models used to test stationarity of the real exchange rate are likely to be misspeciÞed ...
Hunter, J, Simpson, M
core  

POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 Lactylation

open access: yesAdvanced Science, EarlyView.
Schematic diagram of our study showing that highly expressed POU2F1 in colorectal cancer (CRC) can directly accelerate the cytosolic lactate export to decrease PPP1R11 lactylation at K59, thereby attenuating the E3 ligase enzyme activity and protein stability of PPP1R11, which inhibits the ubiquitination of MDR2 at K413 and K538 but increases the ...
Longzheng Xia   +8 more
wiley   +1 more source

On-road vehicle emissions measurements show a significant reduction in black carbon and nitrogen oxide emissions in Euro 6c and 6d diesel-powered cars [PDF]

open access: yesAtmospheric Chemistry and Physics
Real-world vehicle emissions measurement methods were developed to bridge the gap between laboratory tests and actual on-road emissions, including the variability in vehicles, drivers, and environmental conditions.
I. Ježek Brecelj   +9 more
doaj   +1 more source

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

open access: yesAdvanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li   +25 more
wiley   +1 more source

Optimisation and validation of Plume Chasing for robust and automated NOx and particle vehicle emission measurements

open access: yesAtmospheric Environment: X
High-emitting vehicles comprise a small proportion (50%) of vehicle emissions. Plume Chasing is a reliable, high-precision measurement technique that derives emissions without interfering with the vehicle being tested.
Christina Schmidt   +11 more
doaj   +1 more source

Prenatal genesis of layer II doublecortin expressing neurons in neonatal and young adult guinea pig cerebral cortex

open access: yesFrontiers in Neuroanatomy, 2015
Cells expressing doublecortin (DCX+) occur at cortical layer II, predominantly over the paleocortex in mice/rats, but also across the neocortex among larger mammals.
Yan eYang   +8 more
doaj   +1 more source

SIRT1 Prevents Ferroptosis in Corneal Epithelial Cells by Enhancing HIF1α Protein Stability in Dry Eye Disease

open access: yesAdvanced Science, EarlyView.
Hyperosmotic stress drives ferroptosis in corneal epithelium via SIRT1 downregulation. This work demonstrates that SIRT1 activation stabilizes HIF1α, which transcriptionally upregulates GPX4 to inhibit lipid peroxidation and cell death. The identified SIRT1/HIF1α/GPX4 axis reveals a novel defense mechanism and potential therapy for dry eye disease ...
Lili Lian   +11 more
wiley   +1 more source

Depletion of p75NTR in Schwann Cells Driven by Inflammation Mediates Cutaneous Pain in Psoriasis

open access: yesAdvanced Science, EarlyView.
Psoriasis‐like inflammation induces proliferation and molecular remodeling of cutaneous Schwann cells, marked by reduced p75NTR and increased NGF expression. IL‐17A promotes this process, whereas Schwann cell‐specific p75NTR overexpression alleviates cutaneous pain in vivo.
Yibo Wang   +9 more
wiley   +1 more source

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