Results 31 to 40 of about 243,283 (319)

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

AGGRESSIVE BEHAVIORS AND THEIR EFFECT ON RESOURCE USE BY MALE LITTLE BROWN SKINKS, SCINCELLA LATERALIS [PDF]

, 2017
The aggressive behaviors of adult male Little Brown Skinks, Scincella lateralis, and their effects on access to an important resource (a single retreat) were the subject of a study consisting of 10 laboratory trials in which the behavioral interactions ...
Myers, Laura, Paulissen, Mark
core   +2 more sources

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Respostas fisiológicas de estresse no matrinxã (Brycon amazonicus) após exercício físico intenso durante a captura Physiological stress responses of matrinxã (Brycon amazonicus) after chasing

Acta Amazonica, 2009
Para determinar as respostas de estresse do matrinxã após perseguição com puçá, juvenis (26,7±6,7 g) foram aclimatados em caixas plásticas e submetidos aos tratamentos: Controle (sem perseguição), Perseguição por 2 minutos, Perseguição por 5 minutos ...
Márcio Aquio Hoshiba, Flávio Daolio Gonçalves, Elisabeth Criscuolo Urbintati   +2 more
doaj   +1 more source

The rise and fall of e-cigarette cloud chasing appealing to youth

Preventive Medicine Reports, 2021
Electronic cigarette (e-cigarette) use continues to rise among youth with new devices and technology outpacing regulation. The “cloud chasing” phenomenon, whereby vapers compete or otherwise showcase the production of large or artistic exhaled aerosols ...
Emma Brett, Robert Krissinger, Andrea King   +2 more
doaj   +1 more source

Chasing extreme blazars with INTEGRAL

, 2013
Within the blazar population, hard X-ray selected objects are of particular interest as they tend to lie at each end of the blazar sequence. In particular, flat spectrum radio quasars located at high redshifts display the most powerful jets, the largest ...
Bassani, Loredana, Bazzano, A., Bird, A. J., Landi, R., Malizia, A., Molina, M., Ubertini, P.   +6 more
core   +1 more source

Agenda chasing and contests among news providers [PDF]

, 2017
This article studies competition in contests with a focus on the news industry that is increasingly influenced by social media. The model assumes publishers to pick a single topic from a large pool based on the topics' prior “success” probabilities ...
Katona, Z, Knee, JA, Sarvary, M
core   +1 more source

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Pushing towards the Limit of Sampling Rate: Adaptive Chasing Sampling

, 2015
Measurement samples are often taken in various monitoring applications. To reduce the sensing cost, it is desirable to achieve better sensing quality while using fewer samples.
Li, Ying, Wang, Xin, Xie, Kun
core   +1 more source