Results 31 to 40 of about 467,777 (116)

Exosomal circRNA derived from gastric tumor promotes white adipose browning by targeting the miR‐133/PRDM16 pathway

International Journal of Cancer, 2019
Cancer‐related cachexia is a metabolic syndrome characterized by a wasting disorder of adipose and skeletal muscle and is accompanied by body weight loss and systemic inflammation.
Haiyang Zhang, Lei Zhu, M. Bai, Ying Liu, Yang Zhan, T. Deng, Haiou Yang, Wu Sun, Xin-Yi Wang, Kegan Zhu, Q. Fan, Jia-Lu Li, G. Ying, Y. Ba   +13 more
semanticscholar   +1 more source

Serum-derived exosomes induce proinflammatory cytokines production in Cynoglossus semilaevis via miR-133-3p.

Developmental and Comparative Immunology, 2022
Exosomes are small membrane-enclosed vesicles secreted by various types of cells. In mammals, a wide range of physiological and pathological functions have been confirmed and attributed to EVs carrying a variety of molecular cargoes, including miRNAs ...
Zhanpeng Sun, Xiaozhu Liu, M. Lu, Xiao Zhang, Jinsheng Sun   +4 more
semanticscholar   +1 more source

A statistical approach to enhance the productivity of Streptomyces baarensis MH-133 for bioactive compounds

Synthetic and Systems Biotechnology
The goal of this study was to use statistical optimization to change the nutritional and environmental conditions so that Streptomyces baarensis MH-133 could make more active metabolites.
Mohamed H. Kalaba, Gamal M. El-Sherbiny, O. Darwesh, Saad A. Moghannem   +3 more
semanticscholar   +1 more source

Exploring the anti-inflammatory effects of postbiotic proteins from Lactobacillus delbrueckii CIDCA 133 on inflammatory bowel disease model.

International Journal of Biological Macromolecules
Lactobacillus delbrueckii CIDCA 133 is a promising health-promoting bacterium shown to alleviate intestinal inflammation. However, the specific bacterial components responsible for these effects remain largely unknown.
Andria Dos Santos Freitas, F. A. L. Barroso, G. Campos, M. Americo, Rhayane Cristina Dos Santos Viegas, Gabriel Camargos Gomes, K. D. Vital, Simone O. A. Fernandes, R. D. de Oliveira Carvalho, J. Jardin, Ana Paula Gomes Dos Santos Miranda, Ênio Ferreira, F. Martins, J. Laguna, Gwénaël Jan, V. Azevedo, L. D. de Jesus   +16 more
semanticscholar   +1 more source

Cyclic Peptides KS-133 and KS-487 Multifunctionalized Nanoparticles Enable Efficient Brain Targeting for Treating Schizophrenia

JACS Au
Establishing drug delivery systems (DDSs) for transporting drugs from peripheral tissues to the brain is crucial for treating central nervous system diseases.
K. Sakamoto, Seigo Iwata, Zihao Jin, Lu Chen, Tatsunori Miyaoka, M. Yamada, Kaiga Katahira, R. Yokoyama, Ami Ono, S. Asano, Kotaro Tanimoto, R. Ishimura, S. Nakagawa, Takatsugu Hirokawa, Yukio Ago, Eijiro Miyako   +15 more
semanticscholar   +1 more source

Safety, Tolerability, and Pharmacokinetics of Crenezumab in Patients with Mild-to-Moderate Alzheimer’s Disease Treated with Escalating Doses for up to 133 Weeks

Journal of Alzheimer's Disease, 2020
Background: Crenezumab is a fully humanized, monoclonal anti-amyloid-β immunoglobulin G4 antibody. Objective: This Phase Ib study (NCT02353598) evaluated the safety, tolerability, and pharmacokinetics of crenezumabat doses of ≤120 mg/kg administered ...
H. Guthrie, L. Honig, Helen Lin, K. Sink, K. Blondeau, A. Quartino, M. Dolton, M. Carrasco-Triguero, Q. Lian, T. Bittner, D. Clayton, Jillian Smith, S. Ostrowitzki   +12 more
semanticscholar   +1 more source

RGD-PEG-PLA Delivers MiR-133 to Infarct Lesions of Acute Myocardial Infarction Model Rats for Cardiac Protection

Pharmaceutics, 2020
Studies have shown that microRNA-133 (miR-133) plays a positive role in the growth of cardiac myocytes, the maintenance of cardiac homeostasis, and the recovery of cardiac function, which is of great significance for the recovery of acute myocardial ...
Bixi Sun, Shuwen Liu, Rubin Hao, Xinyue Dong, Lanbo Fu, B. Han   +5 more
semanticscholar   +1 more source

Upregulation of circ‐FBL promotes myogenic proliferation in myasthenia gravis by regulation of miR‐133/PAX7

Cell Biology International, 2021
Myasthenia gravis (MG) is a disease involving neuromuscular transmission that causes fatigue of skeletal muscles and fluctuating weakness. It has been shown that impairment of myogenic differentiation and myofiber maturation may be the underlying cause ...
Xiaoyin Lai, Zhuajin Bi, Xue-Lian Yang, Rongguo Hu, Lu Wang, Mingming Jin, Long-Xuan Li, Bitao Bu   +7 more
semanticscholar   +1 more source

Phenotype, penetrance, and treatment of 133 CTLA-4-insufficient subjects

Journal of Allergy and Clinical Immunology, 2018
Background: Cytotoxic T‐lymphocyte antigen 4 (CTLA‐4) is a negative immune regulator. Heterozygous CTLA4 germline mutations can cause a complex immune dysregulation syndrome in human subjects. Objective: We sought to characterize the penetrance, clinical
C. Schwab, Annemarie Gabrysch, P. Olbrich, V. Patiño, K. Warnatz, D. Wolff, A. Hoshino, M. Kobayashi, K. Imai, M. Takagi, I. Dybedal, J. Haddock, D. Sansom, J. Lucena, M. Seidl, A. Schmitt-Graeff, V. Reiser, F. Emmerich, N. Frede, A. Bulashevska, U. Salzer, D. Schubert, Seiichi Hayakawa, S. Okada, M. Kanariou, Z. Kucuk, H. Chapdelaine, L. Petruželková, Z. Šumník, A. Šedivá, M. Slatter, P. Arkwright, A. Cant, H. Lorenz, T. Giese, V. Lougaris, A. Plebani, C. Price, K. Sullivan, M. Moutschen, J. Litzman, T. Freiberger, F. L. van de Veerdonk, M. Recher, M. Albert, F. Hauck, S. Seneviratne, J. P. Schmid, A. Kolios, G. Unglik, C. Klemann, C. Speckmann, S. Ehl, A. Leichtner, R. Blumberg, A. Franke, S. Snapper, S. Zeissig, C. Cunningham-Rundles, L. Giulino-Roth, O. Elemento, G. Dückers, T. Niehues, E. Froňková, V. Kanderova, C. Platt, J. Chou, T. Chatila, R. Geha, E. McDermott, S. Bunn, M. Kurzai, A. Schulz, L. Alsina, F. Casals, À. Deyà-Martínez, S. Hambleton, H. Kanegane, K. Taskén, O. Neth, B. Grimbacher   +80 more
semanticscholar   +1 more source

YBX-1 mediated sorting of miR-133 into hypoxia/reoxygenation-induced EPC-derived exosomes to increase fibroblast angiogenesis and MEndoT

Stem cell research & therapeutics, 2019
Myocardial fibrosis is a common pathophysiological change in cardiovascular disease, which can cause cardiac dysfunction and even sudden death. Excessively activated fibroblasts proliferate and secret excessive extracellular matrix (ECM) components ...
Feng-Xia Lin, Zhi-Cong Zeng, Yin-Zhi Song, Liang Li, Zijun Wu, Xiaoduo Zhang, Zhiwen Li, Xiao Ke, Xun Hu   +8 more
semanticscholar   +1 more source