Results 61 to 70 of about 75,730 (262)

Synchronous Telecollaboration for Novice Language Learners: Effects on Speaking Skills and Language Learning Interests

open access: yesALSIC: Apprentissage des Langues et Systèmes d'Information et de Communication, 2017
Telecollaboration brings together learners in different parts of the world for collaborative language learning and cultural exchange. Defined by Belz as the "application of global communication networks in foreign language education" (2002: 61 ...
Theresa Schenker
doaj   +1 more source

Stiffness‐Programmable Origami Robots With Tendon‐Driven Actuation via Multimaterial 3D Printing

open access: yesAdvanced Robotics Research, EarlyView.
Motion diversity is achieved in a tendon‐driven origami robot through programmable stiffness rather than modified actuation. Multimaterial 3D printing embeds soft creases, modular inserts redirect identical tendon inputs into distinct behaviors, and variable‐stiffness inserts enable real‐time switching.
Elisha Lerner, Jianguo Zhao
wiley   +1 more source

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

open access: yesAdvanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong   +14 more
wiley   +1 more source

MASH Background Confers Enhanced Disease Susceptibility and Acetaminophen Toxicity in iPSC‐Derived Liver Organoids

open access: yesAdvanced Science, EarlyView.
This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha   +5 more
wiley   +1 more source

Implementación de un servicio de referencia virtual por chat en una biblioteca universitaria argentina

open access: yesRevista Española de Documentación Científica, 2009
En el presente trabajo se comentará la experiencia de la biblioteca Joaquín V. González de la facultad de Ciencias Jurídicas y Sociales de la Universidad Nacional de La Plata (Argentina) en la implementación y puesta en marcha de un servicio de ...
Marina Borrell, Evangelina Maciel
doaj   +1 more source

RBM10 Deficiency Promotes Anti‐PD‐1 Resistance in LUAD via STING Alternative Splicing‐Driven CCL7 Signaling and Macrophage Polarization

open access: yesAdvanced Science, EarlyView.
RBM10 deficiency promotes anti‐PD‐1 resistance in lung adenocarcinoma by altering STING alternative splicing, which enhances CCL7 secretion and CCR2‐dependent M2 macrophage polarization. A positive feedback loop via mitochondrial transfer sustains this immunosuppression.
Weitong Gao   +14 more
wiley   +1 more source

Enhancing Maturation of Human Neuromuscular Organoids via Electrical Stimulation

open access: yesAdvanced Science, EarlyView.
A framework for on‐demand and non‐invasive exposure of human neuromuscular organoids (NMOs) to electrical stimuli is established to promote their maturation. The robustness and effectiveness of different stimulation regimes are evaluated via thorough characterization of organoid tissue structure and contraction capacity. Chronic electrical stimulation,
Chrysanthi‐Maria Moysidou   +12 more
wiley   +1 more source

Jaufré Rudel's 'love from afar' and distant love via chat; a metaphorical approach

open access: yesDigithum, 2006
Love for an unknown person in a distant location has featured spectacularly throughout the history of literature. One of the emblematic authors who dealt with falling in love in such a blind fashion was the troubadour Jaufré Rudel, to the extent that he ...
Pau Gerez
doaj  

CCL3 and IL‐7 Synergistically Enhance CAR‐T Efficacy in Solid Tumors

open access: yesAdvanced Science, EarlyView.
Synergistic delivery of CCL3 and IL‐7 by CAR‐T cells overcomes the immunosuppressive tumor microenvironment by enhancing cell infiltration, survival, and local immune reprogramming. This also establishes positive feedback that amplifies anti‐tumor activity and memory responses in both CAR‐T and endogenous T cells, presenting a robust therapeutic ...
Huanpeng Chen   +12 more
wiley   +1 more source

O amor pode ser virtual? O relacionamento amoroso pela Internet ¿Puede el amor ser virtual? Un estudio sobre el relacionamiento virtual usando la internet Can love be virtual? Affective relationships through the Internet

open access: yesPsicologia em Estudo, 2008
Este estudo teve como finalidade contribuir para o entendimento de uma nova modalidade de relacionamento - o virtual. Dele participaram 50 usuários brasileiros da Internet, que responderam a um questionário contendo 31 questões sobre opiniões e ...
Alessandra dos Santos Menezes Dela Coleta   +2 more
doaj   +1 more source

Home - About - Disclaimer - Privacy