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Progerin Hinders Autophagy Flux at Its Final Stages in Hutchinson‐Gilford Progeria Syndrome Cells, Preventing Its Own Autophagic Degradation

Aging Cell, Volume 25, Issue 8, August 2026.
We demonstrated that progerin induces the formation of autophagosomes but impairs their maturation and subsequent fusion with lysosomes. Progerin impedes proper autophagy flux, thus preventing its own autophagic degradation. Selinexor treatment improved both autophagosome maturation and autophagosome‐lysosome fusion, which ultimately led to effective ...
Ian García‐Aguirre +18 more
wiley +1 more source

Il vaccino coniugato antipneumococcico 21-valente per la prevenzione delle infezioni da Streptococcus pneumoniae in età adulta: una valutazione di Health Technology Assessment. [PDF]

J Prev Med Hyg
Calabrò GE +23 more
europepmc +1 more source

Arboreal Mammals Are at Risk Under Climate Change: Insights From a Global Systematic Review and Meta‐Analysis

Global Change Biology, Volume 32, Issue 8, August 2026.
Climate change is increasingly impacting arboreal mammals, yet these effects vary across regions and taxa, and global syntheses to inform conservation priorities remain limited. This study presents the first global synthesis of climate change impacts on arboreal mammals using a systematic review, meta‐analysis, and bibliometric analysis.
Dinayadura Kalathma Navanjalie Samanthi De Silva, Carly Campbell, Grant Hamilton +2 more
wiley +1 more source

Set configuration influences cardiovascular responses to resistance exercise in postmenopausal females in a randomized crossover trial from the CARE project. [PDF]

Sci Rep
Rúa-Alonso M +6 more
europepmc +1 more source

Hodgkin and non‐Hodgkin lymphomas in the post‐antiretroviral therapy era according to HIV virological suppression

HIV Medicine, Volume 27, Issue 8, Page 1312-1332, August 2026.
Abstract Objectives Lymphomas remain among the most frequent HIV‐associated malignancies, with risk persisting despite effective virological control. This study describes the clinical, epidemiological and prognostic characteristics of lymphomas (both Hodgkin [HL] and non‐Hodgkin [NHL]) in people living with HIV (PLWH), according to virological ...
Teresa Aldámiz‐Echevarria +555 more
wiley +1 more source

Computational Investigation of the Potential Antileishmanial Mechanism of the Nitroindazole Derivative VATR131. [PDF]

Pharmaceuticals (Basel)
Casanova-Alvarez O +7 more
europepmc +1 more source

Pollinator efficiency, rather than bee decline, explains a shift to hummingbird pollination in tropical montane forests

New Phytologist, Volume 251, Issue 4, Page 2237-2247, August 2026.
Hummingbird pollination is a hallmark of American plant diversity and has long been thought to evolve in tropical mountains due to declining bee activity. Using sister species of Costus specialized on bees (C. kuntzei) and hummingbirds (C. wilsonii), we show that this shift is not driven by reduced bee visitation with elevation, but by greater ...
Pedro Juárez +7 more
wiley +1 more source

Physical activity level in women with primary dysmenorrhea: A cross-sectional observational study. [PDF]

Womens Health (Lond)
Naia Z, Santos PC, Bello O.
europepmc +1 more source

Commodification anxiety and the memory of Turkish revolutionary Deniz Gezmiş. [PDF]

Mem Stud
Erbil D.
europepmc +1 more source

Enhanced Extraction and Separation with HPLC-DAD of Phenolic and Flavonoid Antioxidants from Portulaca oleracea L. Leaves Using Tailored Terpenoid-Based NADES: Comparative Assessment of Antiradical and Antimicrobial Activities. [PDF]

Antioxidants (Basel)
Sebbah T +6 more
europepmc +1 more source

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