Association Between Use of a Primary Care Health Check-Up Tool and the Early Detection of Chronic Diseases: A Non-Randomised Comparative Study from the POZ PLUS Pilot Programme in Poland. [PDF]
Medicina (Kaunas)Małecka D +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Association between preventive health management and high-risk drinking among women of childbearing age: a correlational study of the ninth Korea National Health and Nutrition Examination Survey. [PDF]
Womens Health NursLee HJ, Kim HY.
europepmc +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Effectiveness of roadside alcohol testing in reducing fatal accidents and fatal drinking-driving accidents: A multi-city study in China. [PDF]
PLoS OneLi F, Nie X.
europepmc +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
From the perspective of the Construal Level Theory: Examining the effect of psychological distance on system justification. [PDF]
Br J Soc PsycholScarci F +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Scientific Reviewing-Editors' Memo to Emerging Reviewers - 2. [PDF]
J Epidemiol Glob HealthEbrahim SH, Memish ZA.
europepmc +1 more source