Results 171 to 180 of about 4,406,721 (399)
Molecular Oncology, EarlyView.Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran +16 more
wiley +1 more source
The Astrophysical JournalThe observed chemical diversity of Milky Way stars places important constraints on Galactic chemical evolution and the mixing processes that operate within the interstellar medium. Recent works have found that the chemical diversity of disk stars is low.
Catherine Manea +5 more
doaj +1 more source
Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer
Molecular Oncology, EarlyView.This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu +7 more
wiley +1 more source
The First Chemical Census of the Milky Way’s Nuclear Star Cluster
The Astrophysical Journal LettersAn important step in understanding the formation and evolution of the nuclear star cluster (NSC) is to investigate its chemistry and chemical evolution. Additionally, exploring the NSC’s relationship to the other structures in the Galactic center and the
Govind Nandakumar +6 more
doaj +1 more source
Recovering true metal abundances of the ICM [PDF]
arXiv, 2001 Recovering the true average abundance of the intracluster medium (ICM) is crucial for estimates of its global metal content, which in turn is linked to its past evolution and to the star formation history of the stellar component of the cluster. We analyze here how the presence of abundance gradients affects commonly adopted estimates of the average ...
arxiv
Metal Abundances in Nearby Stars and the Chemical History of the Solar Neighbourhood [PDF]
, 1975 B. E. J. Pagel, B. E. Patchett
openalex +1 more source
KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
Molecular Oncology, EarlyView.We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock +10 more
wiley +1 more source
What Can We Learn from the Nitrogen Abundance of High-z Galaxies?
The Astrophysical JournalWe present measurements of the gas-phase oxygen and nitrogen abundances obtained by applying the direct method to JWST NIRspec R ∼ 1000 spectroscopy for six galaxies at redshift greater than 3.
Massimo Stiavelli +11 more
doaj +1 more source
The Sunburst Arc with JWST. III. An Abundance of Direct Chemical Abundances
The Astrophysical JournalAbstract We measure the gas-phase abundances of the elements He, N, O, Ne, S, Ar, and Fe in an individual H ii region known to be leaking Lyman-continuum photons in the Sunburst Arc, a highly magnified galaxy at redshift z = 2.37. We detect the temperature-sensitive auroral lines [S ii] λλ4070, 4076, [O iii] λ4363, [S ...
Brian Welch +13 more
openaire +3 more sources
Molecular Oncology, EarlyView.CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar +4 more
wiley +1 more source