Results 201 to 210 of about 4,473,250 (366)

The Open Cluster Chemical Abundances and Mapping Survey. VIII. Galactic Chemical Gradient and Azimuthal Analysis from SDSS/MWM DR19

The Astronomical Journal
The Open Cluster Chemical Abundances and Mapping (OCCAM) survey seeks to curate a large, comprehensive, uniform dataset of open clusters and member stars to constrain key Galactic parameters.
Jonah M. Otto, Peter M. Frinchaboy, Natalie R. Myers, James W. Johnson, John Donor, Ahabar Hossain, Szabolcs Mészáros, Hailey Wallace, Katia Cunha, Binod Bhattarai, Amaya Sinha, Gail Zasowski, Sarah R. Loebman, Alessa I. Wiggins, Adrian M. Price-Whelan, Taylor Spoo, Diogo Souto, Dmitry Bizyaev, Kaike Pan, Andrew K. Saydjari, Ying-Yi Song   +20 more
doaj   +1 more source

Chemical feature of Eu abundance in the Draco dwarf spheroidal galaxy [PDF]

, 2015
Takuji Tsujimoto, Miho N. Ishigaki, Toshikazu Shigeyama, Wako Aoki   +3 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Figuring Out Gas and Galaxies In Enzo (FOGGIE). VIII. Complex and Stochastic Metallicity Gradients at z > 2

The Astrophysical Journal
Gas-phase metallicity gradients are a crucial element in understanding the chemical evolution of galaxies. We use the FOGGIE simulations to study the metallicity gradients (∇ Z ) of six Milky Way–like galaxies throughout their evolution.
Ayan Acharyya, Molly S. Peeples, Jason Tumlinson, Brian W. O’Shea, Cassandra Lochhaas, Anna C. Wright, Raymond C. Simons, Ramona Augustin, Britton D. Smith, Eugene Hyeonmin Lee   +9 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Under Pressure: Decoding the Effect of High Densities on Derived Nebular Properties

The Astrophysical Journal
Recent JWST observations have uncovered a population of compact, high-redshift ( z  > 6) galaxies exhibiting extreme nebular conditions and enhanced nitrogen abundances that challenge standard chemical evolution paradigms.
Zorayda Martinez, Danielle A. Berg, Bethan L. James, Karla Z. Arellano-Córdova, Daniel P. Stark, Peter Senchyna, Evan D. Skillman, Noah S. J. Rogers, John Chisholm   +8 more
doaj   +1 more source

Chemical abundances in metal-poor giants: limitations imposed by the use of classical 1D stellar atmosphere models [PDF]

, 2011
V. Dobrovolskas, A. Kučinskas, H.‐G. Ludwig, E. Caffau, J. Klevas, D. Prakapavičius   +5 more
openalex   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Determining Stellar Elemental Abundances from DESI Spectra with the Data-driven Payne

The Astrophysical Journal Supplement Series
Stellar abundances for a large number of stars provide key information for the study of Galactic formation history. Large spectroscopic surveys such as the Dark Energy Spectroscopic Instrument (DESI) and LAMOST take median-to-low-resolution ( R ≲ 5000 ...
Meng Zhang, Maosheng Xiang, Yuan-Sen Ting, Jiahui Wang, Haining Li, Hu Zou, Jundan Nie, Lanya Mou, Tianmin Wu, Yaqian Wu, Jifeng Liu   +10 more
doaj   +1 more source