Results 91 to 100 of about 852,367 (264)

Accelerated Ostwald Ripening by Chemical Activity

Journal of the American Chemical Society
Phase separation of biomolecular condensates promotes membrane-free compartmentalization in cells. The dynamics of these biocondensates is routinely regulated by energy-consuming processes. Here, we devise a theory pinpointing how active chemical reactions, interconverting molecules between phase-separating and inert forms, can drive faster condensate ...
Benjamin Sorkin, Ned S. Wingreen
openaire   +5 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Hazelnut Shells as a Tenable Biosorbent for Basic Red 18 Azo Dye Removal

Separations
The increasing pollution from the textile industry, particularly organic azo dyes, presents a significant environmental challenge, necessitating the development of effective and sustainable treatment methods.
Naji Agilee, Tijana Spasojević, Milica Delić, Đorđe Ogrizović, Isabel R. Gria, Nevena Prlainović, Maja Đolić   +6 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

PPE Waste-Derived Carbon Materials for Energy Storage Applications via Carbonization Techniques

C
Starting from the COVID-19 pandemic in early 2020, billions of personal protective equipment (PPE), mainly face masks (FMs), are reported to be worn and thrown away every month worldwide.
Nur Amaliyana Raship, Siti Nooraya Mohd Tawil, Murniati Syaripuddin   +2 more
doaj   +1 more source

Clustering of chemically propelled nanomotors in chemically active environments

Chaos: An Interdisciplinary Journal of Nonlinear Science
Synthetic nanomotors powered by chemical reactions have been designed to act as vehicles for active cargo transport, drug delivery, and a variety of other uses. Collections of such motors, acting in consort, can self-assemble to form swarms or clusters, providing opportunities for applications on various length scales.
Narender Khatri, Raymond Kapral
openaire   +4 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Development and Characterization of Biomass-Derived Carbons for the Removal of Cu²⁺ and Pb²⁺ from Aqueous Solutions

C
This research explores the synthesis and application of carbon-based adsorbents derived from olive stones and almond shells as low-cost biomass precursors through carbonization at 600 °C combined with chemical activation using KOH, H3PO4, and ZnCl2 with ...
Vahid Rahimi, Catarina Helena Pimentel, Diego Gómez-Díaz, María Sonia Freire, Massimo Lazzari, Julia González-Álvarez   +5 more
doaj   +1 more source