Results 131 to 140 of about 767,411 (260)

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

Energy-Dense High-Fat/High-Sucrose Diet to Induce Type 2 Diabetes Mellitus in BALB/c Mice Without Genetic Modifications and Chemical Agents. [PDF]

open access: yesBiology (Basel)
Diaz-Herreros AN   +7 more
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

open access: yesFEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Editorial: Metals in medicine

open access: yesFrontiers in Chemistry, 2022
Zhe Liu, Christian Hartinger, Nora Kulak
doaj   +1 more source

ACEGEN: Reinforcement Learning of Generative Chemical Agents for Drug Discovery. [PDF]

open access: yesJ Chem Inf Model
Bou A   +12 more
europepmc   +1 more source

Residual decontamination chemical agents negatively affect adhesion and proliferation of osteoblast-like cells on implant surface. [PDF]

open access: yesInt J Implant Dent, 2020
Balderrama ÍF   +6 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

New chemical agents based on adamantane-monoterpene conjugates against orthopoxvirus infections. [PDF]

open access: yesRSC Med Chem, 2020
Suslov EV   +10 more
europepmc   +1 more source

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