Results 131 to 140 of about 16,837,088 (341)

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

More than tears: associations between exposure to chemical agents used by law enforcement and adverse reproductive health outcomes. [PDF]

Front Epidemiol, 2023
Hassan A, Ojanen-Goldsmith A, Hing AK, Mahoney M, Traxler S, Boraas CM.   +5 more
europepmc   +1 more source

Chemical Warfare Agents: Medical Aspects and Treatment Principles, Part II

, 2007
he most effective means of defending against chemical warfare agents, whether in war or as result of terror, are by use of primary and secondary prevention.
Matteo Guidotti, Massimo C Ranghieri, Alessandra Rossodivita, Elisaveta Jasna Stikova   +3 more
core  

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

The dangerous link between coal dust exposure and DNA damage: unraveling the role of some of the chemical agents and oxidative stress. [PDF]

Environ Geochem Health, 2023
Miranda-Guevara A, Muñoz-Acevedo A, Fiorillo-Moreno O, Acosta-Hoyos A, Pacheco-Londoño L, Quintana-Sosa M, De Moya Y, Dias J, de Souza GS, Martinez-Lopez W, Garcia ALH, da Silva J, Borges MS, Henriques JAP, León-Mejía G.   +14 more
europepmc   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

An experimental study to measure oil recovery factor by chemical agents and carbon dioxide after waterflooding. [PDF]

Sci Rep, 2022
Yang G, Bai Y, Song Y, Metwally ASM, Mahmoud O.   +4 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Impediment effect of chemical agents (additives) on gluten development in cookie dough. [PDF]

J Food Sci Technol, 2022
Ahmad S, Naz A, Usman M, Amjad A, Pasha I, Farooq U.   +5 more
europepmc   +1 more source