Results 151 to 160 of about 3,162 (208)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

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Immunological alterations and chemical exposure

Journal of Toxicology: Clinical Toxicology, 1989
The complex nature of the immune system with its multiple humoral and cellular components makes it an easy target for many drugs and chemicals. Immunotoxicology is defined as an adverse response of the immune system to a chemical or drug which may result in disease such as autoimmunity, immune suppression, allergy or other hypersensitivity states ...
John B Sullivan
exaly   +3 more sources

Alterations in the structure of deoxyribonucleic acid on chemical methylation

Biochemistry, 1971
A I Krasna, Alvin I Krasna
exaly   +3 more sources

Reviewing Vital Bleaching and Chemical Alterations

Journal of the American Dental Association, 1991
exaly   +3 more sources

Alteration of the Specificity of Lectin by Chemical Modification

The Journal of Immunology, 1963
Summary Acylation of lima bean and Sophora japonica lectins with p- phenylazobenzoyl chloride greatly increased the anti-A agglutinating activity and, in the case of S. japonica, diminished the anti-B and anti-O activity. Amino acid analyses of purified peptides isolated from the modified lectins suggested that the change in specificity ...
S, MATSUBARA, W C, BOYD
openaire   +3 more sources

Chemical alteration of cervical mucus by electrolytes

American Journal of Obstetrics and Gynecology, 1983
Scanning electron microscopy and energy-dispersive x-ray analysis have been used, together with conventional light microscopy and sperm penetration tests, to evaluate the alteration of cervical mucus composition and properties during the menstrual cycle and subsequent to exposure of cervical mucus to electrolytes in vitro and in vivo. Alteration of the
K G, Gould, A H, Ansari
openaire   +2 more sources

DNA methylome alterations in chemical carcinogenesis

Cancer Letters, 2013
Carcinogenesis, a complex multifactorial process of the transformation of normal cells into malignant cells, is characterized by many biologically significant and interdependent alterations triggered by the mutational and/or non-mutational (i.e., epigenetic) events. One of these events, specific to all types of cancer, is alterations in DNA methylation.
Igor P, Pogribny, Frederick A, Beland
openaire   +2 more sources

Metamict and chemically altered vesuvianite

The Canadian Mineralogist, 1993
Partly metamict vesuvianite samples from two localities were examined and compared. The unit cell of one is enlarged owing to volume expansion caused by the buildup of radiation damage. The other sample sustained enough damage to exclude accurate determination of unit-cell parameters.
R. K. Eby, J. Janeczek, R. C. Ewing, T. S. Ercit, L. A. Groat, B. C. Chakoumakos, F. C. Hawthorne, G. R. Rossman   +7 more
openaire   +1 more source

Chemical induced alterations in p53 signaling

2009
The p53 protein is one of the most important tumor suppressors. The present review summarizes aspects of p53 function and its role in cancer development. Some of the most well-characterized molecular mechanisms affecting p53 regulation, stabilization, inactivation and downstream events are described.
Johan, Högberg, Ilona, Silins, Ulla, Stenius   +2 more
openaire   +2 more sources

Biotite Flakes: Alteration by Chemical and Biological Treatment

Science, 1967
Biotite alteration under acid conditions proceeds differently from the generally accepted pathway of transformation to vermiculite in which hydrated cations cause interlayer expansion, resulting in a dark-colored peripheral band on mica particles.
J R, Boyle, G K, Voigt, B L, Sawhney
openaire   +2 more sources