Results 131 to 140 of about 1,063,418 (267)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Integrated metagenomic and soil chemical analyses revealed shifts of microbial nutrient cycling with poplar plantation age. [PDF]

Front Plant Sci
You Y, Liu X, Wang L, Khalid M, Wang X, Jiang L, Wang F, Pang Z, Peng Y, Zhao X.   +9 more
europepmc   +1 more source

Community Composition, Antifungal Activity and Chemical Analyses of Ant-Derived Actinobacteria. [PDF]

Front Microbiol, 2020
Wang Z, Yu Z, Zhao J, Zhuang X, Cao P, Guo X, Liu C, Xiang W.   +7 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Storage domains of coniferin in cell wall forming tracheid cells in Pinus thunbergii stems evaluated by cryo microscopic chemical analyses. [PDF]

Sci Rep
Aoki D, Iwamaru K, Nishida S, Uchida T, Li B, Isomura Y, Yoshida M, Inagaki T, Fukushima K.   +8 more
europepmc   +1 more source

The integrative taxonomy of Beauveria asiatica and B. bassiana species complexes with whole-genome sequencing, morphometric and chemical analyses.

Persoonia, 2021
Kobmoo N, Arnamnart N, Pootakham W, Sonthirod C, Khonsanit A, Kuephadungphan W, Suntivich R, Mosunova OV, Giraud T, Luangsa-Ard JJ.   +9 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Antibacterial Activity and Chemical Analyses of the Alkaloidal Fraction of <i>Neltuma laevigata</i> (Humb. & Bonpl. Ex Willd) Britton & Rose Inflorescences. [PDF]

Molecules
Nava-Solis U, Rodriguez-Canales M, Hernandez-Hernandez AB, Flores-Ortíz CM, Rodriguez-Monroy MA, Canales-Martinez MM.   +5 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Rapid ¹³C Solid-State Quantitative NMR Method for Multiple Physical and Chemical Analyses of Cocoa-Based Products: Proof of Concept. [PDF]

Anal Chem
Tobias TJ, Efraim P, de Moraes TB, Colnago LA.   +3 more
europepmc   +1 more source