Results 11 to 20 of about 3,980 (199)

A Regular D‑optimal Weighing Design with Negative Correlations of Errors

Acta Universitatis Lodziensis. Folia Oeconomica, 2019
The issues concerning optimal estimation of unknown parameters in the model of chemical balance weighing designs with negative correlated errors are considered. The necessary and sufficient conditions determining the regular D‑optimal design and some new
Małgorzata Graczyk, Bronisław Ceranka
doaj   +1 more source

On Highly D-Efficient Designs with Nonnegatively Correlated Observations

Revstat Statistical Journal, 2017
In the most difficult case where the number of observations n ≡ 3 (mod 4), high D-efficiency of certain chemical balance weighing designs under completely symmetric covariance matrix of errors is shown. It is also proved that D-optimal design may depend
Krystyna Katulska , Lukasz Smaga
doaj   +1 more source

Some D-optimal chemical balance weighing designs: theory and examples

, 2017
Summary In this paper we study a certain kind of experimental designs called chemical balance weighing designs. We consider issues with regard to determining optimality conditions.
B. Ceranka, M. Graczyk
semanticscholar   +1 more source

Remarks about a construction method for D-optimal chemical balance weighing designs

, 2019
Summary This paper presents some constructions of regular D-optimal weighing designs based on the incidence matrices of a balanced incomplete block design, balanced bipartite weighing design and ternary balanced block design.
M. Graczyk, Malwina Janiszewska
semanticscholar   +1 more source

A note on D-optimal chemical balance weighing designs with autocorrelated observations

, 2016
In this paper, D-optimal chemical balance weighing designs with three objects are considered. The error terms are assumed to form a first-order autoregressive process, which implies that the covariance matrix of the vector of errors depends on the known ...
Łukasz Smaga
semanticscholar   +1 more source

Estimation of Unknown Object Measures in a Chemical Weighing Design with Correlated Errors

Acta Universitatis Lodziensis. Folia Oeconomica
In this paper, some problems that concern the determining of unknown measurements of objects in the model of a chemical balance weighing design are presented.
Małgorzata Graczyk, Bronisław Ceranka
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source