Results 101 to 110 of about 4,446,617 (245)

Crystallography in Chemistry; Current Profile of Chemical Crystallography

Nihon Kessho Gakkaishi, 2014
Hidehiro UEKUSA, Yoshiki OHGO, Tomoji OZEKI   +2 more
openaire   +3 more sources

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Inertial mixing of acoustically levitated droplets for time‐lapse protein crystallography

Droplet
Varying the chemical consistency of acoustically levitated droplets opens up an in situ study of chemical and biochemical reactions in small volumes. However, the optimization of the mixing time and the minimization of the positional instability induced ...
Soichiro Tsujino, Yohei Sato, Shichao Jia, Michal W. Kepa, Sofia Trampari, Takashi Tomizaki   +5 more
doaj   +1 more source

Dynamic three-dimensional structures of a metal–organic framework captured with femtosecond serial crystallography

Nature Chemistry
Crystalline systems consisting of small-molecule building blocks have emerged as promising materials with diverse applications. It is of great importance to characterize not only their static structures but also the conversion of their structures in ...
Jaedong Kang, Yunbeom Lee, Seonggon Lee, H. Ki, Jungmin Kim, J. Gu, Yongjun Cha, Jun Heo, Kyung Won Lee, Seong Ok Kim, Jaehyun Park, Sang-Youn Park, Sangsoo Kim, Rory Ma, I. Eom, Minseok Kim, Jeongho Kim, Jae Hyuk Lee, H. Ihee   +18 more
semanticscholar   +1 more source

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

Coordination Polymers of Vanadium and Selected Metal Ions with N,O-Donor Schiff Base Ligands—Synthesis, Crystal Structure, and Application

Molecules
This review provides an overview of the synthesis, characterization and application of coordination polymers based on N,O-donor Schiff base ligands.
Dariusz Osypiuk, Agata Bartyzel, Beata Cristóvão   +2 more
doaj   +1 more source

Protein Structuromics Reveals a Loop‐Controlled Half‐Open Active Pocket Conformation Throughout Fe(II)/α‐ketoglutarate‐Dependent Dioxygenase Catalytic Cycle

Advanced Science, EarlyView.
This study reveals a conserved half‐open active pocket in Fe(II)/α‐ketoglutarate‐dependent dioxygenases through protein structuromics, distinguished by structural features comprising highly flexible loop elements. Enhanced sampling simulations‐guided mutagenesis experiments elucidated how this flexible loop regulates pocket open/closed conformations ...
Lunjie Wu, Huan Liu, Songyin Zhao, Lei Qin, Jiarui Li, Jun Wang, Zixuan Dai, Jie Gu, Yan Xu, Feiran Li, Yao Nie   +10 more
wiley   +1 more source

Exploration of Ruthenium(II/III/VI)–Salen Complexes: From Synthesis to Functional Applications

Molecules
This review provides a comprehensive overview of recent advances in the synthesis, structural characterization, and applications of Ru(II), Ru(III), and Ru(VI) complexes, which bear tetradentate Schiff bases of salen type.
Beata Cristóvão, Dariusz Osypiuk, Agata Bartyzel   +2 more
doaj   +1 more source

A General Enzymatic Strategy for Site‐Specific Incorporation of Modified Genetic Building Blocks Into DNA

Advanced Science, EarlyView.
Eco‐friendly enzymatic synthesis of high‐fidelity, site‐specifically modified DNA using 3′‐blocked nucleotides for full synthetic control and next‐generation sequencing compatibility. ABSTRACT Methods for site‐specific incorporation of modified DNA building blocks remain limited.
Raveena Raveena, Bhavana Ramadas, Sidney Becker   +2 more
wiley   +1 more source

New Water Oxidation Mechanism in Photosystem II Resolves Major Experimental Controversies

Angewandte Chemie, EarlyView.
In Photosystem II Oxygen Evolving Complex, we discovered the O3‐O6 peroxide at lower energy. Assignment of the O3 ligated by histidine (His337) as a slow exchanging substrate and its coupling with O6 give the O─O bond formation mechanism most consistent with all currently available experimental data. Proposal shows how protein environment can steer the
Yulia Pushkar
wiley   +2 more sources