Results 101 to 110 of about 6,156,385 (293)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

The Influence of Annealing on the Structural, Optical and Electrical Properties of Copper Selenite Nanocrystals Synthesized by the Chemical Deposition Method

open access: yesCrystals
This work presents a study of copper selenite nanocrystals, obtained for the first time by chemical deposition (template synthesis) in a SiO2/Si track template, and investigates their properties.
Gulnaz Sarsekhan   +9 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Decoration of silicon structures by chemical deposition of nanostructured copper films on porous silicon

open access: yesДоклады Белорусского государственного университета информатики и радиоэлектроники, 2019
The results of experimental study of formation regularities, structural and optical properties of nanostructured copper films chemically deposited on porous silicon from solutions of copper sulfate and hydrofluoric acid are presented.
L. Yu. Roshchin, A. V. Bondarenko
doaj  

Deposition behavior of TiB2 by microwave heating chemical vapor deposition (CVD)

open access: yesGreen Processing and Synthesis, 2015
Microwave heating chemical vapor deposition (CVD) is used to deposit titanium diboride (TiB2) films on graphite substrate using a gas mixture of TiCl4, BCl3, H2 and Ar.
Lu Shuaidan   +5 more
doaj   +1 more source

Deposition of silicon nitride films using chemical vapor deposition for photovoltaic applications

open access: yesResults in Physics, 2016
Silicon nitride is a versatile material since many decades due to its compatibility with conventional fabrication technology. Other than its potential applications in microelectronics, this material has been regarded as an antireflection coating in solar
K. Jhansirani   +3 more
doaj   +1 more source

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