Results 41 to 50 of about 38,633 (256)
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
On statistical evaluation of reverse degree based topological indices for iron telluride networks
Scientific ReportsIn the context of graph theory and chemical graph theory, this research conducts a detailed mathematical investigation of reverse topological indices as they relate to iron telluride networks, clarifying their complex interactions.
Maged Z. Youssef +5 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Structural Analysis and Topological Characterization of Sudoku Nanosheet
Journal of Mathematics, 2022 The physical and biological properties of chemical compounds are modelled using chemical graph theory. The geometric structure of chemical compounds can be modelled using a variety of topological indices derived from graph theory. The chemical structures,
Shahid Zaman +3 more
doaj +1 more source
Computation of Several Banhatti and Reven Invariants of Silicon Carbides
مجلة بغداد للعلوم, 2023 Expressions for the molecular topological features of silicon carbide compounds are essential for quantitative structure-property and structure-activity interactions.
Abid Mahboob +3 more
doaj +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Topological Characterization of Carbon Graphite and Crystal Cubic Carbon Structures
Molecules, 2017 Graph theory is used for modeling, designing, analysis and understanding chemical structures or chemical networks and their properties. The molecular graph is a graph consisting of atoms called vertices and the chemical bond between atoms called edges ...
Wei Gao +3 more
doaj +1 more source
Cyclic connectivity index of bipolar fuzzy incidence graph
Open Chemistry, 2022 In the performance characterization of chemical molecular structures, several uncertain properties are often encountered, and fuzzy theory is precisely the tool to characterize these uncertainties.
Lu Juanjuan, Zhu Linli, Gao Wei
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source