Results 81 to 90 of about 367,971 (281)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Partition Resolvability of Nanosheet and Nanotube Derived from Octagonal Grid

Journal of Mathematics
Chemical graph theory, a branch of computational and applied mathematics, covers a very wide range of topics. As a result, the world of applied sciences heavily relies on graph theory.
Ali Al Khabyah, Ali N. A. Koam, Ali Ahmad   +2 more
doaj   +1 more source

Some degree-based topological indices of caboxy-terminated dendritic macromolecule

Main Group Metal Chemistry, 2021
In the modern era of the chemical science, the chemical graph theory has contributed significantly to exploring the properties of the chemical compounds.
Rao Yongsheng, Kanwal Ammarah, Abbas Riffat, Noureen Saima, Fahad Asfand, Qureshi Muhammad Imran   +5 more
doaj   +1 more source

Thermal Operator Representation of Finite Temperature Graphs

, 2005
Using the mixed space representation (t,p) in the context of scalar field theories, we prove in a simple manner that the Feynman graphs at finite temperature are related to the corresponding zero temperature diagrams through a simple thermal operator ...
A. Das, Ashok Das, F. T. Brandt, H. Umezawa, J. Frenkel, J. I. Kapusta, L. V. Keldysh, L. V. Keldysh, M. L. Bellac, Olivier Espinosa, R. Kubo, Silvana Perez, Y. Takahashi   +12 more
core   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Eccentricity Based Topological Indices of an Oxide Network

Mathematics, 2018
Graph theory has much great advances in the field of mathematical chemistry. Chemical graph theory has become very popular among researchers because of its wide applications in mathematical chemistry.
Muhammad Imran, Muhammad Kamran Siddiqui, Amna A. E. Abunamous, Dana Adi, Saida Hafsa Rafique, Abdul Qudair Baig   +5 more
doaj   +1 more source

Quasichemical theory and the description of associating fluids relative to a reference: Multiple bonding of a single site solute

, 2017
We derive an expression for the chemical potential of an associating solute in a solvent relative to the value in a reference fluid using the quasichemical organization of the potential distribution theorem.
Asthagiri, D., Bansal, Artee, Chapman, Walter G.   +2 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Edge-based metric resolvability of anti-depression molecular structures and its application

Results in Chemistry
Chemical graph theory represents an interdisciplinary field at the intersection of chemistry and mathematics, focusing on the analysis of various chemical structures through graph-theoretical frameworks.
Rab Nawaz, Muhammad Kamran Jamil, Muhammad Azeem   +2 more
doaj   +1 more source