Results 51 to 60 of about 7,468,932 (307)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Risk Management Dimensions in CBRNE Incidents: A Scoping Review for Hospital Preparedness [PDF]

Health in Emergencies & Disasters Quarterly
Background: Hospital management must focus on maintaining preparedness and ensuring a safe environment for both staff and patients during crises. This study aimed to determine the dimensions of risk management in chemical, biological, radiological ...
Taha Nasiri, Akbar Javan Biparva
doaj  

Quantification of Risk Reduction Due to the Installation of Different Lightning Protection Solutions for Large Atmospheric Storage Tanks

Chemical Engineering Transactions, 2014
In the past decades the impact of natural events in industrial plants have triggered a number of technological accidents. Accidents may be followed by the release of relevant quantities of hazardous substances, with relevant consequences for the ...
A. Necci, G. Antonioni, V. Cozzani, A. Borghetti, C.A. Nucci   +4 more
doaj   +1 more source

Substantiation of proposals on the use of insulating apparatus in the liquidation of emergencies with the release of hazardous chemicals

Technology audit and production reserves, 2018
In work, the technical possibilities of using personal respiratory protective equipment are considered as an object of research. Such funds are used in fire and rescue units, during emergency rescue operations related to the liquidation of emergency situations with the release of hazardous chemicals.
Borodych, Pavlo, Deyneko, Natalya, Kovalev, Pavlo, Streletc, Victor, Shevchenko, Roman   +4 more
openaire   +3 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Analysis and Simulation of Severe Accidents in a Steam Methane Reforming Plant

International Journal of Occupational Hygiene, 2015
Severe accidents of process industries in Iran have increased significantly in recent decade. This study quantitatively analyzes the hazards of severe accidents imposed on people, equipment and building by a hydrogen production facility.
Mohammad Javad Jafari, Iraj Mohammadfam, Esmaeil Zarei   +2 more
doaj  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Evaluation of Thermal Hazard Properties of Low Temperature Active Azo Compound under Process Conditions for Polymer Resin in Construction Industries

, 2021
The application of polymerization initiators in a process can improve reaction efficiency and reduce energy loss. Azo compounds (azos) provide the required energy and promote polymerization for construction due to the heat release in the decomposition ...
Chia-Feng Tsai, I-Jyh Wen
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source