Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Changing the structure of PFOA and PFOS: a chemical industry strategy or a solution to avoid thyroid-disrupting effects? [PDF]
J Endocrinol InvestCoperchini F, Greco A, Rotondi M.
europepmc +1 more source
FEBS Open Bio, EarlyView.5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
RETRACTED: Impact of High-Frequency Traveling-Wave Magnetic Fields on Low-Conductivity Liquids: Investigation and Potential Applications in the Chemical Industry. [PDF]
Materials (Basel)Cui X, Na X, Wang X, Ernst R, Yves F.
europepmc +1 more source
Climate change mitigation potential of carbon capture and utilization in the chemical industry. [PDF]
Proc Natl Acad Sci U S A, 2019 Kätelhön A +4 more
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FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
RETRACTED: Cui et al. Impact of High-Frequency Traveling-Wave Magnetic Fields on Low-Conductivity Liquids: Investigation and Potential Applications in the Chemical Industry. Materials 2024, 17, 944. [PDF]
Materials (Basel)Cui X, Na X, Wang X, Ernst R, Yves F.
europepmc +1 more source
Breaking the state-of-the-art in the chemical industry with new-to-Nature products via synthetic microbiology. [PDF]
Microb Biotechnol, 2019 Martinelli L, Nikel PI.
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