Results 101 to 110 of about 1,921,756 (289)

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

What do we want to estimate from observational datasets? Choosing appropriate statistical analysis methods based on the chemical management phase. [PDF]

Integr Environ Assess Manag, 2022
Takeshita KM, Hayashi TI, Yokomizo H.
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

CHEMICAL INDUSTRY RISK MANAGEMENT – RISK QUANTIFICATION

Nonconventional Technologies Review, 2022
This paper deals with problems in the metalworking industry concerning occupational health and safety, specifically chromium, and carbon monoxide poisoning. A subjective risk assessment is carried out, the data are quantified in a risk matrix suggesting
Anca CristiMA Tatarcan, Victoria Petroesc, Augustin Semenescu   +2 more
doaj  

Review of best management practices for aquatic vegetation control in stormwater ponds, wetlands, and lakes [PDF]

, 2013
Auckland Council (AC) is responsible for the development and operation of a stormwater network across the region to avert risks to citizens and the environment.
Champion, Paul, Clayton, John, de Winton, Mary, Edwards, Tracey, Hamilton, David P., Hofstra, Deborah, Jones, Hannah Frances Emily, McBride, Chris G., Rowe, David K., Wells, Rohan, Özkundakci, Deniz   +10 more
core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Management of chemical incidents [PDF]

Journal of Public Health, 1998
H, Bowen, D, Fone, H, Fielder
openaire   +2 more sources

Stanford Linear Accelerator Center: A Chemical Management Services Case Study [PDF]

, 2008
The Chemical Management Services (CMS) program at Stanford Linear Accelerator Center (SLAC)was launched in August of 2005. In the first six months of the program, there were 170 users in 35 work areas requesting more than 1,600 different chemicals from a

core  

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source