Results 51 to 60 of about 1,921,756 (289)

CHEMICAL HAZARDS ASSOCIATED WITH PESTICIDES MANAGEMENT

open access: yesArta Medica, 2020
Objectives. The study presents the estimation of the use level of phytosanitary products in the Republic of Moldova, during the years 2012-2019, and their impact on the population health.
Iurie Pînzaru   +3 more
doaj   +1 more source

Perspectives on information and supply chains within investment banking [PDF]

open access: yes, 2008
Supply chain concepts are usually confined to industries where there are core sourcing, manufacture and delivery processes. These industries are usually to be found within the industrial products, aerospace, automotive, chemical and pharmaceutical ...
Sharif, AM
core  

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Key aspects on the biology, ecology and impacts of johnsongrass [Sorghum halepense (L.) Pers] and the role of glyphosate and non-chemical alternative practices for the management of this weed in Europe [PDF]

open access: yes, 2019
Sorghum halepense (L.) Pers is a common and noxious worldwide weed of increasing distribution in many European countries. In the present review, information on the biology, ecology, agricultural, economic and environmental impact of johnsongrass is given,
Antonopoulos, Nikolaos   +9 more
core   +3 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

Developing a Numerical Water Quality Model for Brewster Lake [PDF]

open access: yes, 2014
The purpose of this research study was to develop an advanced two-dimensional process-oriented numerical water quality model for Brewster Lake that incorporates the physical, chemical, and biological interactions that occur within the lake.
Aljobeh, Zuhdi   +2 more
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Development of organic fertilizers from food market waste and urban gardening by composting in Ecuador [PDF]

open access: yes, 2017
Currently, the management of urban waste streams in developing countries is not optimized yet, and in many cases these wastes are disposed untreated in open dumps.
Bustamante, M. Ángeles   +3 more
core   +2 more sources

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

open access: yesMolecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande   +11 more
wiley   +1 more source

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