Results 61 to 70 of about 1,924,634 (308)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

GROWTH AND INITIAL DEVELOPMENT OF 'SMOOTH CAYENNE' AND 'PÉROLA' PINEAPPLE CULTIVARS, AFTER POST-PLANTING HERBICIDES' APPLICATION

Colloquium Agrariae, 2019
There was a lack of information regarding the use of herbicides in pineapple crop, so the aim was to evaluate the growth and initial development of 'Smooth Cayenne' and 'Pérola' pineapple seedlings under application of diuron, sulfentrazone and ametryn ...
André Felipe Moreira Silva, Gustavo Soares da Silva, Ana Carolina Viviani Pagenotto, Ana Ligia Giraldeli, Júlia Pereira de Moraes, Beatriz Sizilio dos Santos, Giovani Apolari Ghirardello, Ricardo Victoria Filho   +7 more
doaj  

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A modified NK algorithm based on BP neural network and DEMATEL for evolution path optimization of urban innovation ecosystem

Complex & Intelligent Systems, 2021
In the new era, the key measure to accelerate the construction of smart city, so as to promote the modernization of urban governance system and governance capacity, is to establish a good urban innovation ecosystem, and guide its continuous evolution to ...
Ruijian Liu, Fangcheng Tang, Yuhan Wang, Shaofang Zheng   +3 more
doaj   +1 more source

Chemical Container Management System

, 2023
{"references": ["1.\tBayram, Atilla, Sulaiman Abdullah Moammed, and F\u0131rat Kara. 2016. Design of Heating System Controlled by Arduino. In 4th International Symposium on Innovative Technologies in Engineering and Science, 1583\u20131591.", "2.\tAbdullah, Rina, Zairi Ismael, Rizman, Nik Nur Shaadah Nik, Dzulkefli, SyilaIzawana, Ismail, Rosmawati ...
Dr A R JayaSudha, Jeyandhan D
openaire   +1 more source

Developing a Numerical Water Quality Model for Brewster Lake [PDF]

, 2014
The purpose of this research study was to develop an advanced two-dimensional process-oriented numerical water quality model for Brewster Lake that incorporates the physical, chemical, and biological interactions that occur within the lake.
Aljobeh, Zuhdi, Brunsvold, Sarah, Marley, Kasey   +2 more
core   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Can “energy-saving and emission reduction” demonstration city pilot alleviate carbon inequality in Chinese cities?

Discover Sustainability
As a pivotal element in China’s pursuit of a sustainable development model, green fiscal policies have become increasingly important amid the exacerbation of global climate conditions.
Yong Fang, Minghao Li, Xueyan Chen, Chuyuan Wang   +3 more
doaj   +1 more source

The impact of the EU carbon border adjustment mechanism on China based on the climate club

Carbon Management
This study analyzes the EU Carbon Border Adjustment Mechanism (CBAM)’s implications for China’s trade, GDP, and carbon emissions under evolving global climate governance frameworks.
Tong Yue, Lu Liu, Yi Xie, Xuezhi Liu
doaj   +1 more source