Results 101 to 110 of about 883,463 (344)
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
Molecular Oncology, EarlyView.The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova +18 more
wiley +1 more source
Effect of β-PVDF Piezoelectric Transducers’ Positioning on the Acoustic Streaming Flows
Micromachines, 2014 This paper reports the numerical and experimental analysis of the acoustic streaming effect in a fluidic domain. The actuation of a piezoelectric transducer generates acoustic waves that propagate to the fluids, generating pressure gradients that induce ...
Susana O. Catarino +2 more
doaj +1 more source
Relaxation Phenomena in a Bistable Chemical System
, 1984 A theoretical investigation is presented of the relaxation dynamics of a simple model which gives a near-quantitative description of the iodate-excess arsenous acid systems (1). Near the hysteresis limits (K≳ K1, K≲ K2, K= input flow rate) and near the critical point K an exact expression is obtained for the nonlinear response to a sudden change of the
Dewel, Guy +2 more
openaire +3 more sources
Numerical modeling tools for chemical vapor deposition [PDF]
Development of general numerical simulation tools for chemical vapor deposition (CVD) was the objective of this study. Physical models of important CVD phenomena were developed and implemented into the commercial computational fluid dynamics software ...
Childs, Edward P., Jasinski, Thomas J.
core +1 more source
Molecular Oncology, EarlyView.Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop +10 more
wiley +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Multidisciplinary research activity in the materials sciences with emphasis on ceramic materials Semiannual status report, 16 Dec. 1966 - 15 Jun. 1967 [PDF]
Ceramic materials science - chemical effects, surface phenomena, solid state ceramics, and ...
Mueller, J. I.
core +1 more source
Normal state Nernst effect, semiconducting-like resistivity and diamagnetism of underdoped cuprates [PDF]
, 2005 Semiconducting-like low-temperature in-plane resistivity indicates that there are no remnants of superconductivity above the resistive phase transition at T > Tc in underdoped cuprates.
Alexandrov, A. S.
core +1 more source
Percolation-dependent Reaction Rates in the Etching of Disordered Solids
, 2002 A prototype statistical model for the etching of a random solid is investigated in order to assess the influence of disorder and temperature on the dissolution kinetics.
Kolwankar, K. M., Plapp, M., Sapoval, B.
core +1 more source