Results 41 to 50 of about 247,881 (266)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Obtención de tetróxido de trimanganeso (Hausmanita) y sulfato de potasio a partir de residuos de laboratorio [PDF]

Avances en Química, 2009
Obtainment of trimanganese tetroxide (Hausmanite) and potassium sulfate from laboratory wastes. In the laboratory practices a great amount of solutions is generated that, by their dangerous characteristics, cannot be rejected to the environment.
Katiuska Ramos
doaj  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Self-healing mechanisms of water-conducting fractures：The influence of chemical precipitation induced by the mixing of different groundwater

Meitan xuebao, 2023
In the long-term evolution process after the development of the water-conducting fractures in overburden, the self-healing phenomenon will occur, in which the water-conducting seepage capacity will gradually decrease. It is of great significance to study
Quansheng LI, Jinfeng JU, Jialin XU, Zhiguo CAO, Kai ZHANG, Chenyu WANG, Junting GUO   +6 more
doaj   +1 more source

Electrical Precipitation in the Chemical Industry [PDF]

Journal of Industrial & Engineering Chemistry, 1922
n ...
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Synthesis and Research of Alumina Ceramics Properties

Chimica Techno Acta, 2020
The article describes in detail alumina powder synthesis by different methods at varying parameters. The technique of obtaining ceramics and the research of the optical properties for determining the materials with the maximum luminescence efficiency is ...
Evgeniy I. Frolov, Polina V. Notina, Sergey V. Zvonarev, Evgeniya A. Il'ina, Vyacheslav Yu. Churkin   +4 more
doaj   +1 more source

SEWAGE PURIFICATION BY SEPTIC TANK AND CHEMICAL PRECIPITATION. [PDF]

Journal of the American Medical Association, 1907
The obvious impossibility of discussing in any detail either the septic tank or chemical treatment of sewage, in the twenty or thirty minutes allotted, makes it necessary that the subject be treated very generally, depending on the discussion which may follow to bring out special points of interest.
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source