Results 161 to 170 of about 1,137,365 (218)

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Nonadiabatically Driven Quantum Interference Effects in the Ultracold K + KRb → Rb + K₂ Chemical Reaction. [PDF]

J Phys Chem Lett
da Silva H, Kendrick BK, Li H, Kotochigova S, Balakrishnan N.   +4 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Control of a Gel-Forming Chemical Reaction Network Using Light-Triggered Proton Pumps. [PDF]

Langmuir
Figueiredo da Silva J, Roshanasan A, Bus M, Fotiadis D, Knoll AW, van Esch JH, Wolf H.   +6 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Basal State Calibration of a Chemical Reaction Network Model for Autophagy. [PDF]

Int J Mol Sci
Hajdú B, Kapuy O, Nagy T.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Macrocycle Unidirectional Transport Along a Linear Molecule by a Two-Step Chemical Reaction Sequence. [PDF]

ChemistryOpen
Catalán AC, Peña-Zarate L, Cervantes R, Vela A, Tiburcio J.   +4 more
europepmc   +1 more source

Nanoscale chemical reaction exploration with a quantum magnifying glass. [PDF]

Nat Commun
Csizi KS, Steiner M, Reiher M.
europepmc   +1 more source

Microbial Metabolomics' Latest SICRIT: Soft Ionization by Chemical Reaction In-Transfer Mass Spectrometry. [PDF]

J Am Soc Mass Spectrom
McAtamney A, Ferranti A, Ludvik DA, Yildiz FH, Mandel MJ, Hayward T, Sanchez LM.   +6 more
europepmc   +1 more source