Results 221 to 230 of about 2,750,647 (290)

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Chemical Reaction Simulator on Quantum Computers by First Quantization (II)─Basic Treatment: Implementation. [PDF]

J Chem Theory Comput
Takahashi H, Tomaru T, Hirano T, Tahara S, Sato F.   +4 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

γ‑Butyrolactone Synthesis from Allylic Alcohols Using the CO2 Radical Anion

Precision Chemistry
Saeesh R. Mangaonkar, Hiroki Hayashi, Wataru Kanna, Suvankar Debbarma, Yu Harabuchi, Satoshi Maeda, Tsuyoshi Mita   +6 more
doaj   +1 more source

Computational modeling and thermal analysis of magnetized nanofluid flow with physio-chemical interaction and chemical reaction between two non-parallel walls. [PDF]

Front Chem
Sohail S, Shah Z, Rooman M, Khan W, Alshehri MH, Vrinceanu N, Antonescu E.   +6 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

ORDerly: Data Sets and Benchmarks for Chemical Reaction Data. [PDF]

J Chem Inf Model
Wigh DS, Arrowsmith J, Pomberger A, Felton KC, Lapkin AA.   +4 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

PCA-based synthetic sensitivity coefficients for chemical reaction network in cancer. [PDF]

Sci Rep
Biddau G, Caviglia G, Piana M, Sommariva S.   +3 more
europepmc   +1 more source

Computation Implemented by the Interaction of Chemical Reaction, Clustering, and De-Clustering of Molecules. [PDF]

Biomimetics (Basel)
Gunji YP, Adamatzky A.
europepmc   +1 more source