Results 101 to 110 of about 335,422 (272)

Quantum Information Processing in the Radical-Pair Mechanism: Haberkorn theory violates the Ozawa entropy bound

, 2017
Radical-ion-pair reactions, central for understanding the avian magnetic compass and spin transport in photosynthetic reaction centers, were recently shown to be a fruitful paradigm of the new synthesis of quantum information science with biological ...
Kominis, I. K., Mouloudakis, K.
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Machine learning-guided synthesis of prospective organic molecular materials: An algorithm with latent variables for understanding and predicting experimentally unobservable reactions

Artificial Intelligence Chemistry
Chemists have traditionally relied on heuristic approaches to qualitatively assess chemical structure–property relationships and interpret experimental outcomes.
Kazuhiro Takeda, Naoya Ohtsuka, Toshiyasu Suzuki, Norie Momiyama   +3 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Are we close to the QGP? - Hadrochemical vs. microscopic analysis of particle production in ultrarelativistic heavy ion collisions [PDF]

, 2005
Ratios of hadronic abundances are analyzed for pp and nucleus-nucleus collisions at sqrt(s)=20 GeV using the microscopic transport model UrQMD. Secondary interactions significantly change the primordial hadronic cocktail of the system.
Bass, Steffen A., Belkacem, Mohamed, Bleicher, Marcus, Brandstetter, Mathias, Gerland, Lars, Greiner, Walter, Konopka, Jens, Neise, Ludwig, Soff, Sven, Spieles, Christian, Stöcker, Horst, Weber, Henning   +11 more
core  

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Hadronization of Expanding QGP

, 2005
We discuss how the dynamics of an exploding hot fireball of quark--gluon matter impacts the actual phase transition conditions between the deconfined and confined state of matter.
Letessier, J., Rafelski, J.
core   +2 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Bulk properties and flow

, 2004
In this report, I summarize the experimental results on {\bf bulk properties and flow} presented at Quark Matter 2004. It is organized in four sections: 1) Initial condition and stopping; 2) Particle spectra and freeze-outs; 3) Anisotropic flow; 4 ...
Accardi A, Adams J (STAR Collaboration), Antinori F, Back B B (PHOBOS Collaboration), Barannikova O, Barnby L, Bleicher M, Braun-Munzinger P, Castillo J, Debbe R, Fachini P, Fries R, Gazdzicki M, Groom D E, Guylassy M, Hwa R, Jaffe B, Kadija K, Kaneta M, Knopfle K-T, Lisa M, Liu X M, Markert C, Matathias F, Murray M, Nagle J, Nouicer R, Nouicer R, Oldenburg M (STAR Collaboration), Pinkenburg C, Poskanzer A, Putschke J (STAR Collaboration), Retière F, Roland G, Ruan L, Schweda K, Sorensen P (STAR Collaboration), STAR Collaboration, Steinberg P, Stock R, Tang A, Teaney D, Tonjes M B, Velkovska J, Veres G, Wang F Q, Zhang H (STAR Collaboration), Zhangbu Xu   +47 more
core   +2 more sources