Results 131 to 140 of about 1,417,488 (251)

Chemical risk assessment at Research Institutions

Journal of Environment and Safety, 2016
Moriyama, Fumiki, Tanaka, Toshinori
openaire   +1 more source

Introducing the 2026 Early Career Board of <i>ACS Medicinal Chemistry Letters</i>. [PDF]

ACS Med Chem Lett
Axtman A, Goldstein S, Hlozek J, Monti L, Shen C, Shevick SL, Uguen M, Vukelic S, Watson E, Xiong R, Zhang X, Zhang Z, De Vita E, Fosu SC, Raouf YS.   +14 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Response to Article “Ultrasensitive Hierarchical AuNRs@SiO2@Ag SERS Probes for Enrichment and Detection of Insulin and C-Peptide in Serum” [Letter]

International Journal of Nanomedicine
Subash CB Gopinath1–3 1Center for Global Health Research, Saveetha Medical College & Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, Tamil Nadu, 602 105, India; 2Faculty of Chemical Engineering & Technology,
Gopinath SCB
doaj  

Democratizing Artificial Intelligence in Toxicology: Real-World Applications and Automated Computational Workflows. [PDF]

Chem Res Toxicol
Mansouri K, Moreira-Filho JT, S Tieghi R, Kleinstreuer N.   +3 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Retraction Note: Evaluation of safety margins of chenopodium album seed decoction: 14-day subacute toxicity and microbicidal activity studies. [PDF]

Reprod Biol Endocrinol
Kumar S, Biswas S, Banerjee S, Mondal NB.   +3 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Correction: Continuous manufacturing of highly stable lead halide perovskite nanocrystals <i>via</i> a dual-reactor strategy. [PDF]

Nanoscale Adv
Liang S, Biesold GM, Zhang M, Kang Z, Wagner B, Lin Z.   +5 more
europepmc   +1 more source