Results 181 to 190 of about 3,025,562 (306)

Research in the field of chemistry and chemical technology at the Belarusian State University (the fortieth anniversary of the Research Institute for Physical Chemical Problems of the BSU)

Журнал Белорусского государственного университета: Химия, 2019
Tatsiana V. Gaevskaya, Yury V. Nechepurenko, Evgenii A. Cherniavsky, Olga N. Vrublevskaya   +3 more
doaj  

ChemGenXplore: an interactive tool for exploring and analysing chemical genomic data. [PDF]

Bioinformatics
Ahmad H, Doherty HM, Benedict ST, Haycocks JRJ, Zhou G, Moynihan PJ, Moradigaravand D, Banzhaf M.   +7 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Corrigendum to "Skin-inspired phototherapeutic cryogel ameliorates infected wound healing by orchestrating mechanotransduction and immunomodulation" [Bioact. Mater. 57 (2026) 768-790]. [PDF]

Bioact Mater
Dutta SD, An JM, Moniruzzaman M, Acharya R, Seol Y, Kim H, Randhawa A, Kim JS, Lee YK, Lim KT.   +9 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

2'-hydroxyl modification improves enzymatic and thermal stability of mRNA. [PDF]

Mol Ther Nucleic Acids
Uchida S.
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Correction: THRUST: translesion synthesis-driven hierarchical regulation using a template-activator construct for Cas12a activity. [PDF]

Chem Sci
Qin L, Wang WJ, Xia X, Zuo T, Cai Y, Xu G, Wei F, Wang S, Hu Q, Zhao Z, Zhang F, Tang BZ, Cen Y.   +12 more
europepmc   +1 more source

Laboratory of Microbiology, The Institute for Physical and Chemical Research (RIKEN)

JOURNAL OF THE BREWING SOCIETY OF JAPAN, 1998
Atsumi NAKAZATO, Toshimori KADOKURA, Kyoko YAMAMOTO, Tadashi HARAYAMA, Moriya OHKUMA, Masahisa TAKEDA, Toshiaki KUDO, Takichi KANEKO   +7 more
openaire   +2 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source