Results 161 to 170 of about 29,234 (209)

C‐Terminal Functionalization Methods of Amino Acids, Peptides, and Proteins

Chemistry – A European Journal, EarlyView.
C‐terminal functionalization offers powerful routes to peptide and protein diversification, yet epimerization, hydrolysis, and selectivity remain key challenges. This Review surveys enzymatic, decarboxylative, and condensation strategies, highlighting advances toward chemo‐ and regioselective, protecting‐group‐free, atom‐efficient methods applicable to
Jay Hanssens, Mark Lambers, Romano V. A. Orru, Jordy M. Saya   +3 more
wiley   +1 more source

Integrating demographic characteristics, settling preference, and field investigation for resistance evaluation of four potato cultivars to Myzus persicae. [PDF]

Pest Manag Sci
Zhang KX, Yang DW, Yan JJ, Gao YL.
europepmc   +1 more source

Gibbs energy minimization thermodynamics for CO2 capture by aqueous amines: Conservation laws, concentration variables, and parameter consistency

The Canadian Journal of Chemical Engineering, EarlyView.
We clarify how Gibbs‐energy‐minimization models for aqueous‐amine CO2 capture fail when conservation constraints and concentration conventions are inconsistent. Exact standard‐state conversions and Reaktoro case studies show that P(CO2)‐loading fits can mask non‐unique parameters and wrong speciation, motivating complete water‐inclusive formulations ...
William R. Smith, William Rutherford, Allan M. M. Leal   +2 more
wiley   +1 more source

Hydrophilic versus hydrophobic implant coatings: A comparative osseointegration study. [PDF]

Bioinformation
Sinha RR, Kashyap S, Sahu GK, Chauhan GK, Mishra P, Mayadevi M.   +5 more
europepmc   +1 more source

Investigating the Cytoskeleton of DRGs Using Cryo‐Electron Microscopy and Deep Learning

Cytoskeleton, EarlyView.
ABSTRACT We describe a method for determining the ultrastructural organization of axons and varicosities of cultured dorsal root ganglion (DRG) neurons using cryogenic electron microscopy (cryo‐EM). Cryo‐EM reveals the dimensions, proximity, and overall organization of biological specimens in a near‐native state, avoiding artifacts of fixation and ...
M. Neal Waxham, Mihir Relan, Matthew T. Swulius, Andrea K. H. Stavoe   +3 more
wiley   +1 more source

Phenotypic and Molecular Features of a Large ODDD Family: Expanding the Spectrum of CX43-Related Disorder. [PDF]

Int J Mol Sci
Ambrosetti I, Palombo F, D'Angeli D, Ormanbekova D, Fiorini C, Pietra A, Cristalli CP, Lodi R, Tonon C, Liguori R, Carelli V, Rizzo G, Vaisfeld A.   +12 more
europepmc   +1 more source

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

Assessing Metal Ion Assignment Accuracy in Protein Data Bank Models via Elemental Spectroscopy. [PDF]

J Chem Inf Model
Snell EH, Grime GW, Webb SM, Costa C, Snell ME, Hunt JF, Tong L, Montelione GT, Zigweid R, Staker BL, Myler PJ, Garman EF.   +11 more
europepmc   +1 more source

Maternal and Neonatal Complications Associated with Breast Cancer Systemic Treatments—A VigiBase Disproportionality Analysis Study

Clinical Pharmacology &Therapeutics, EarlyView.
Pregnancy‐associated breast cancer (PrBC) presents therapeutic challenges. Understanding maternal–fetal safety of systemic anticancer therapies is critical. We performed a case/non‐case disproportionality analysis using the WHO global pharmacovigilance database up to January 2024, to evaluate maternal–fetal outcomes associated with breast cancer (BC ...
Rayan Kabirian, Floriane Jochum, Elise Dumas, Florence Coussy, Kevin Bihan, Bénédicte Lebrun‐Vignes, Barbara Pistilli, Marc‐Antoine Benderra, Lise Selleret, Laurent Chouchana, Fabien Reyal, Anne‐Sophie Hamy, Paul Gougis   +12 more
wiley   +1 more source

Endogenous Lipid Signals in Energy Homeostasis and Fibrosis. [PDF]

Biomolecules
Di Meo C, Palaniappan S, Urbano C, Cimino G, Cestra F, De Dominicis N, Carnicelli V, Tisi A, Maccarrone M.   +8 more
europepmc   +1 more source