Results 141 to 150 of about 2,425 (254)

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Phosphoproteomics unveils the signaling dynamics in neuronal cells stimulated with insulin and insulin-like growth factors. [PDF]

Cell Commun Signal
Ushakumary MG, Sontag RL, Posso C, Fillmore TL, Topping ME, Olson HM, De Jager PL, Bennett DA, Arvanitakis Z, Petyuk VA.   +9 more
europepmc   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Nicotine biosynthesis is completed by cryptic activating glucosylation. [PDF]

Nat Commun
Schwabe BTW, Angstman IM, Vollheyde K, Ingold Z, Li J, Stankevich KS, Spicer CD, Fascione MA, Grogan G, Geu-Flores F, Lichman BR.   +10 more
europepmc   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Temperature dependent chemical shifts of pyruvate and lactate enable in vivo hyperpolarized ¹³C MRSI thermometry. [PDF]

Npj Imaging
Gottwald W, Nagel L, Skinner JG, Grashei M, Sühnel S, Setzer N, Eisenreich W, McLean MA, Gallagher FA, Park JM, Ahmadova Z, Gierse M, Karaali S, Knecht S, Schwartz I, Heid I, Topping GJ, van Heijster FHA, Schilling F.   +18 more
europepmc   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Early Detection of Cell Death Using Transmembrane Water Exchange Magnetic Resonance Imaging. [PDF]

Adv Sci (Weinh)
Kaika A, Nagel L, Höckendorf U, Xie B, Topping GJ, Schillmaier M, Beer I, van Heijster FHA, Rauch J, Kuder TA, Sühnel S, Erber B, Lohrmann C, Ballke S, Metzler T, Steiger K, Jost PJ, Ivleva NP, Paprottka P, Nadjiri J, Brindle KM, Weber WA, Schilling F.   +22 more
europepmc   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Proteomic and metabolomic insights into the impact of topping treatment on cigar tobacco. [PDF]

Front Plant Sci
Guo D, Gao H, Yan T, Xia C, Lin B, Xiang X, Cai B, Geng Z.   +7 more
europepmc   +1 more source