Results 161 to 170 of about 6,195,681 (305)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

2010 Summer Transportation Institute

MSU G&C #4W3073MDT Project #6439-041The Summer Transportation Institute (STI) hosted by the Western Transportation Institute at MontanaState University serves to attract high school students to participate in an innovative summereducational program in ...
Gallagher, Susan, Western Transportation Institute   +1 more
core  

Surface tension gradient effects on hybrid nanofluid with activation energy using machine learning technique: Stefan blowing phenomena. [PDF]

MethodsX
Khan I, Kh TI, Abbas M, Liaqat S, Alisherov F, Koh WS.   +5 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Other title: Kansas Department of Transportation 101

, 2018
"January 18, 2018."; Title supplied by the Kansas Department of Transportation website. Alternate title supplied by cataloger.; Presentation before the Kansas Legislature, House Committee on Transportation, by the Kansas Department of ...
Kansas. Department of Transportation.
core  

Analytical Life Cycle Assessment as a 10-Stage Framework for Evaluating and Improving the Sustainability of Analytical Workflows. [PDF]

Anal Chem
Mansour FR, Locatelli M, Omer KM, Mohammed Ameen SS, Bedair A.   +4 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Other title: Kansas Department of Transportation 101; Other title: [Transportation Overview]

, 2017
"January 24, 2017." Title supplied by the Kansas Department of Transportation website. Alternate title supplied by cataloger.; Presentation before the Kansas Legislature, House Committee on Transportation, presented by the Kansas Department of ...
Kansas. Department of Transportation.
core  

Mechanical, Durability, Carbon Footprint, and Economic Assessment of Sand-Gravel-Gneiss Aggregate Mixtures for Sustainable Road Construction. [PDF]

Materials (Basel)
Nowaczek A, Kulczycka J, Bęben M, Kasperek D, Kowalski Z, Makara A, Generowicz-Caba N.   +6 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source