Results 141 to 150 of about 3,625,661 (313)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Enhancing the Activation of Saudi Natural Pozzolan Using Thermal, Mechanical, Chemical, and Hybrid Treatment Approaches

open access: yesBuildings
Saudi Natural Pozzolan (SNP) can be processed and used in construction as a partial replacement for Ordinary Portland Cement (OPC). Its use as a supplementary cementitious material supports more sustainable and eco-friendly building practices. This study
Ardhymanto Am Tanjung   +2 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Research on the Adhesive Properties of Flax Fiber in the Production of Composite Materials

open access: yesTechnologies
The article presents the results of theoretical and experimental research into the adhesive properties of flax fiber and their impact on the scientific development of composite material production.
Sergiy Lavrenko   +2 more
doaj   +1 more source

Surface consolidation of natural stones by use of bio-agents and chemical consolidants [PDF]

open access: yes, 2017
Surface treatment is a frequently used method for conservation and restoration of building materials. . In this study, a novel and environment friendly strategy, bacterially induced calcium carbonate precipitation was applied to strengthen the surface of
Boon, Nico   +5 more
core  

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