Results 171 to 180 of about 19,187,558 (359)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

A Mini-Review on Safe Treatment and Valorization of Salt Waste in Chemical Production Processes in China

open access: yes
In chemical production processes in China, a huge volume of salt waste is produced, contributing to environmental pollution due to the lack of proper treatment procedures to manage this waste effectively. With the current lack of proper treatment methods
Yi Wang   +8 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Plasma-arc technology for the thermal treatment of chemical wastes

open access: yes, 2007
Plasma-arc technology is developed to dispose chemical wastes from a chemical plant by the Institute of Mechanics, Chinese Academy of Sciences. A demo system with this technology is constructed to destroy two sorts of chemical wastes from production ...
李要建   +3 more
core  

An Extensive Analysis of Combined Processes for Landfill Leachate Treatment

open access: yes
Sanitary landfilling is the predominant process for solid urban waste disposal, but it generates leachate that poses environmental, economic, and social concerns.
Zakaria Al-Qodah   +2 more
core   +1 more source

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