Results 61 to 70 of about 111,464 (290)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Chemical thinning of "Sensação" peach trees. [PDF]

, 2022
Peach tree thinning is essential for harvesting quality fruits and maintaining balanced fruit production for several years. Manual thinning of peach trees requires a large workforce, thereby increasing the production costs.
BARRETO, C. F., FARIAS, R. de M., ZANDONÁ, R. R., SCHIAVON, A. V., MARTINS, C. R., FARIAS, P. C. de M.   +5 more
core  

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Bioactivity-guided mapping and navigation of chemical space

, 2009
The structure- and chemistry-based hierarchical organization of library scaffolds in tree-like arrangements provides a valid, intuitive means to map and navigate chemical space.
Schuffenhauer, Ansgar, Seoane, MD, Otterlo, van, W.A.L., Daniel Rauh, Peter Ertl, Renner, S., Brunsveld, Luc, Wetzel, Stefan, Rauh, D, Oprea, Tudor I., Dominguez Seoane, M., Ertl, P, Renner, Steffen, Hofmann, B, Steinhilber, D, Waldmann, H., Ansgar Schuffenhauer, Steffen Renner, Marta Dominguez Seoane, Rauh, Daniel, Luc Brunsveld, Dieter Steinhilber, Renner, S, Möcklinghoff, S., Van Otterlo, Willem A. L., Oprea, TI, Wetzel, S, Schuffenhauer, A, Oprea, T.I., Otterlo, WAL van, Waldmann, Herbert, Ertl, Peter, Rauh, D., Möcklinghoff, Sabine, Willem A L van Otterlo, Herbert Waldmann, Dominguez Seoane, Marta, Oprea, T., Steinhilber, D., Sabine Möcklinghoff, Wetzel, S., Stefan Wetzel, Möcklinghoff, S Sabine, Ertl, P., Schuffenhauer, A., Brunsveld, L Luc, Seoane, M.D., Hofmann, B., Brunsveld, L., Bettina Hofmann, Tudor I Oprea, Hofmann, Bettina, Van Otterlo, W., Steinhilber, Dieter, Brunsveld, L.; id_orcid   +54 more
core   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Original scientific paper

, 2003
: Let n1(e|T) and n2(e|T) denote the number of vertices of a tree T, lying on the two sides of the edge e.LetT1 and T2 be two trees with equal number of vertices, let e be an edge of T1 and f an edge of T2.
Equiseparable Chemical Trees
core  

A generative model for molecule generation based on chemical reaction trees

, 2021
Deep generative models have been shown powerful in generating novel molecules with desired chemical properties via their representations such as strings, trees or graphs.
Nguyen, Dai Hai, Tsuda, Koji
core   +2 more sources