Results 21 to 30 of about 526 (158)

Twenty Five Years of the Laboratory for the Chemical and Analytical Control of the Federal State Budgetary Establishment «27 Scientific Centre» of the Ministry of Defence of the Russian Federation

Вестник войск РХБ защиты, 2023
The Convention on the prohibition of the development, production, stockpiling and use of chemical weapons and on their destruction (CWC) stipulates the realization of the detailed procedure for the verification of the implementation of all its provisions,
I. V. Rybalchenko, V. N. Fateenkov
doaj   +1 more source

The potential of thermal desorption‐GC/MS‐based analytical methods for the unambiguous identification and quantification of perfluoroisobutene and carbonyl fluoride in air samples

Journal of Separation Science, Volume 45, Issue 15, Page 2968-2976, August 2022., 2022
The reactive gases perfluoroisobutene and carbonyl fluoride are highly toxic and difficult to analyze in air. For this paper, the available sampling and analysis methods involving gas chromatography/mass spectrometry were investigated for their potential to give unambiguous identification and quantification of perfluoroisobutene and carbonyl fluoride ...
Håkan Wingfors, Lina Mörén, Daniel Wiktelius, Roger Magnusson   +3 more
wiley   +1 more source

Broad‐Spectrum Antidote Discovery by Untangling the Reactivation Mechanism of Nerve‐Agent‐Inhibited Acetylcholinesterase

Chemistry – A European Journal, Volume 28, Issue 40, July 15, 2022., 2022
Rational design of efficient antidotes to organophosphorus nerve agent (OPNA) intoxication needs to account for the complexity of the molecular system. A fragment with broad‐spectrum binding profile was transformed into a multi‐active reactivator of OPNAs‐inhibited acetylcholinesterases.
Cecilia Lindgren, Nina Forsgren, Norman Hoster, Christine Akfur, Elisabet Artursson, Lotta Edvinsson, Richard Svensson, Franz Worek, Fredrik Ekström, Anna Linusson   +9 more
wiley   +1 more source

Transthyretin as a target of alkylation and a potential biomarker for sulfur mustard poisoning: Electrophoretic and mass spectrometric identification and characterization

Drug Testing and Analysis, Volume 14, Issue 1, Page 80-91, January 2022., 2022
Transthyretin (TTR) was identified by 2D‐thiol‐DIGE and MALDI TOF MS(/MS) as target of alkylating agents, like sulfur mustard (SM). After immunomagnetic separation (IMS) of TTR from SM‐treated plasma and subsequent proteolysis, the specific alkylated hexapeptide C(‐HETE)PLMVK (HETE: SM‐derived hydroxyethylthioethyl‐moiety) was identified by µLC‐ESI MS ...
Wolfgang Schmeißer, Robin Lüling, Dirk Steinritz, Horst Thiermann, Theo Rein, Harald John   +5 more
wiley   +1 more source

International Terrorism Using Toxic Chemicals as an Element of Hybrid Warfare

Вестник войск РХБ защиты, 2023
Modern terrorism is a complex system that consists of a complex of complementary processes – ideological, criminal, military, political, religious and nationalistic.
E. N. Glotov, V. P. Kotov, I. A. Lozanov, M. L. Makarov, О. М. Nikitin, А. М. Fleyer, N. I. Shilo   +6 more
doaj   +1 more source

Identification of creatine kinase and alpha‐1 antitrypsin as protein targets of alkylation by sulfur mustard

Drug Testing and Analysis, Volume 13, Issue 2, Page 268-282, February 2021., 2021
Using the two‐dimensional‐thiol‐differences in gel electrophoresis (2D‐thiol‐DIGE) technique as initial approach to detect proteins with free cysteine residues, peptides containing the residues Cys282 of creatine kinase and Cys232 of alpha‐1 antitrypsin were identified as being alkylated by the chemical warfare agent sulfur mustard (SM).
Robin Lüling, Wolfgang Schmeißer, Markus Siegert, Harald Mückter, Alexander Dietrich, Horst Thiermann, Thomas Gudermann, Harald John, Dirk Steinritz   +8 more
wiley   +1 more source

Federal Directorate for Safe Storage and Destruction of Chemical Weapons – 30th Anniversary

Вестник войск РХБ защиты, 2023
The Russian Federation has ratified the Convention on the Prohibition of the Development, Production, Stockpiling and Use of Chemical Weapons and on Their Destruction, and thereby reaffirmed its international obligations assumed in the field of chemical ...
V. P. Kapashin, V. G. Mandych, S. I. Samarin, I. N. Isaev, I. V. Kovalenko, V. L. Veriga   +5 more
doaj   +1 more source

Investigation of Features of Mass-Fragmentation of Some N-(N,N-diethylacetamidino)-O-alkylfluorophosphates and Related Alkylfluorophosphonates and their Detection by Liquid Chromatography-High Resolution Mass Spectrometry

Вестник войск РХБ защиты, 2023
The timely detection of violations of the Convention on the Prohibition of the Development, Production, Stockpiling  and Use of Chemical Weapons and on Their Destruction (CWC) requires reliable methods for detecting toxic chemicals  that can be used for ...
A. V. Braun, I. V. Rybalchenko, V. N. Fateenkov, V. A. Yashkir   +3 more
doaj   +1 more source

Elaboration of a Method for the Determination of Low-Molecular-Weight Mustard Gas Biomarkers in Biological Samples

Вестник войск РХБ защиты, 2023
The relevance of the development and the improvement of methods for the determination of metabolites (biomarkers) of toxic substances in biological fluids (blood, urine, etc.) is associated with the need to establish facts of humans and animals exposure ...
D. О. Korneev, L. V. Petrakova, М. А. Ponsov, А. А. Rodionov   +3 more
doaj   +1 more source

Identification of acidic degradation products of chemical warfare agents by methylation with trimethylsilyldiazomethane and gas chromatography–mass spectrometry

Journal of Analytical Science and Technology, 2022
Sensitive and reliable analysis of alkylphosphonic acids (APAs) and 2-(N,N-dialkylamino)ethanesulfonic acids (SAs), the degradation products of chemical warfare agents (CWAs), is one of the most important tasks for verification of the Chemical Weapons ...
Marja-Leena Kuitunen, Jean-Claude Dutoit, Peter Siegenthaler, Marja-Leena Rapinoja, Paula Sinikka Vanninen   +4 more
doaj   +1 more source