Results 21 to 30 of about 5,775,816 (164)

The Convention on the Prohibition of the Development, Production, Stockpiling and Use of Chemical Weapons and on their Destruction: History of Signing and Key Points

Вестник войск РХБ защиты, 2020
The Convention on the Prohibition of the Development, Production, Stockpiling and Use of Chemical Weapons and on their Destruction (the Chemical Weapons Convention or CWC) was approved by the U.N. General Assembly on 30 November 1992.
V. N. Fateenkov
doaj   +1 more source

Phosphonylated tyrosine and lysine residues as biomarkers of local exposure of human hair to the organophosphorus nerve agents sarin and VX

Drug Testing and Analysis, Volume 15, Issue 7, Page 730-744, July 2023., 2023
This is the first report addressing analysis of biomarker adducts obtained from human hair exposed to the nerve agents sarin and VX in vitro. Phosphonylated single amino acids were obtained after pronase‐catalyzed proteolysis of hair proteins. Adducted Lys and especially Tyr residues were the most prominent adducts detected by μLC‐ESI MS/HR MS.
Harald John, Tamara Lindl, Henrik Reuter, Wolfgang Schmeißer, Michael Schrader, Horst Thiermann   +5 more
wiley   +1 more source

Twenty Five Years of the Laboratory for the Chemical and Analytical Control of the Federal State Budgetary Establishment «27 Scientific Centre» of the Ministry of Defence of the Russian Federation

Вестник войск РХБ защиты, 2023
The Convention on the prohibition of the development, production, stockpiling and use of chemical weapons and on their destruction (CWC) stipulates the realization of the detailed procedure for the verification of the implementation of all its provisions,
I. V. Rybalchenko, V. N. Fateenkov
doaj   +1 more source

Glutathione conjugation of nitrogen mustards: In vitro study

Rapid Communications in Mass Spectrometry, Volume 37, Issue 9, 15 May 2023., 2023
Rationale This paper describes an in vitro study designed to identify metabolic biomarkers resulting from the conjugation of nitrogen mustards (NMs) with glutathione (GSH). The method developed is essential in providing evidence in the event of NM exposure in biomedical samples.
Nurhazlina Hamzah, Matti Kjellberg, Paula Vanninen   +2 more
wiley   +1 more source

The potential of thermal desorption‐GC/MS‐based analytical methods for the unambiguous identification and quantification of perfluoroisobutene and carbonyl fluoride in air samples

Journal of Separation Science, Volume 45, Issue 15, Page 2968-2976, August 2022., 2022
The reactive gases perfluoroisobutene and carbonyl fluoride are highly toxic and difficult to analyze in air. For this paper, the available sampling and analysis methods involving gas chromatography/mass spectrometry were investigated for their potential to give unambiguous identification and quantification of perfluoroisobutene and carbonyl fluoride ...
Håkan Wingfors, Lina Mörén, Daniel Wiktelius, Roger Magnusson   +3 more
wiley   +1 more source

Federal Directorate for Safe Storage and Destruction of Chemical Weapons – 30th Anniversary

Вестник войск РХБ защиты, 2023
The Russian Federation has ratified the Convention on the Prohibition of the Development, Production, Stockpiling and Use of Chemical Weapons and on Their Destruction, and thereby reaffirmed its international obligations assumed in the field of chemical ...
V. P. Kapashin, V. G. Mandych, S. I. Samarin, I. N. Isaev, I. V. Kovalenko, V. L. Veriga   +5 more
doaj   +1 more source

Broad‐Spectrum Antidote Discovery by Untangling the Reactivation Mechanism of Nerve‐Agent‐Inhibited Acetylcholinesterase

Chemistry – A European Journal, Volume 28, Issue 40, July 15, 2022., 2022
Rational design of efficient antidotes to organophosphorus nerve agent (OPNA) intoxication needs to account for the complexity of the molecular system. A fragment with broad‐spectrum binding profile was transformed into a multi‐active reactivator of OPNAs‐inhibited acetylcholinesterases.
Cecilia Lindgren, Nina Forsgren, Norman Hoster, Christine Akfur, Elisabet Artursson, Lotta Edvinsson, Richard Svensson, Franz Worek, Fredrik Ekström, Anna Linusson   +9 more
wiley   +1 more source

International Terrorism Using Toxic Chemicals as an Element of Hybrid Warfare

Вестник войск РХБ защиты, 2023
Modern terrorism is a complex system that consists of a complex of complementary processes – ideological, criminal, military, political, religious and nationalistic.
E. N. Glotov, V. P. Kotov, I. A. Lozanov, M. L. Makarov, О. М. Nikitin, А. М. Fleyer, N. I. Shilo   +6 more
doaj   +1 more source

Transthyretin as a target of alkylation and a potential biomarker for sulfur mustard poisoning: Electrophoretic and mass spectrometric identification and characterization

Drug Testing and Analysis, Volume 14, Issue 1, Page 80-91, January 2022., 2022
Transthyretin (TTR) was identified by 2D‐thiol‐DIGE and MALDI TOF MS(/MS) as target of alkylating agents, like sulfur mustard (SM). After immunomagnetic separation (IMS) of TTR from SM‐treated plasma and subsequent proteolysis, the specific alkylated hexapeptide C(‐HETE)PLMVK (HETE: SM‐derived hydroxyethylthioethyl‐moiety) was identified by µLC‐ESI MS ...
Wolfgang Schmeißer, Robin Lüling, Dirk Steinritz, Horst Thiermann, Theo Rein, Harald John   +5 more
wiley   +1 more source

Identification of creatine kinase and alpha‐1 antitrypsin as protein targets of alkylation by sulfur mustard

Drug Testing and Analysis, Volume 13, Issue 2, Page 268-282, February 2021., 2021
Using the two‐dimensional‐thiol‐differences in gel electrophoresis (2D‐thiol‐DIGE) technique as initial approach to detect proteins with free cysteine residues, peptides containing the residues Cys282 of creatine kinase and Cys232 of alpha‐1 antitrypsin were identified as being alkylated by the chemical warfare agent sulfur mustard (SM).
Robin Lüling, Wolfgang Schmeißer, Markus Siegert, Harald Mückter, Alexander Dietrich, Horst Thiermann, Thomas Gudermann, Harald John, Dirk Steinritz   +8 more
wiley   +1 more source