Results 111 to 120 of about 1,282,798 (237)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Waste tyres pyrolysis oil (WTPO) as an alternative source of fuel and chemicals: a review

Zaštita Materijala
Waste tyres are dumped and common kind of abandon solid waste. Almost 3 billion tyres are produced each year and each tyre produced will eventually join the waste products and if not properly handled will become pollutant.
Bashir Abdu Muzakkari, Amina Salihi Bayero, Musa Ibrahim Mohammed, Pramod K. Singh, Umar Muhammad Jibreel   +4 more
doaj   +1 more source

Ozone-depleting substances (ODSs) and related chemicals [PDF]

, 2011
The amended and adjusted Montreal Protocol continues to be successful at reducing emissions and atmospheric abundances of most controlled ozone-depleting substances (ODSs).Global Ozone Research and Monitoring ...
Blake, D, Dorf, M, Engel, A, Fraser, P, Froidevaux, L, Jucks, K, Kreher, K, Kruger, K, Kurylo, MK, Mellouki, A, Miller, J, Montzka, SA, Nielsen, O-J, O'Doherty, S, Orkin, VL, Prinn, RG, Reimann, S, Rhew, R, Santee, ML, Stohl, A, Sturges, WT, Verdonik, D   +21 more
core  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Advanced development: Fuels [PDF]

, 1981
The solar thermal fuels and chemicals program at Jet Propulsion Laboratory are described. High technology is developed and applied to displace fossil fuel (oil) use in the production/processing of valuable fuels and chemicals.
Ramohalli, K.
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

A Practical Classification Approach for Chemical, Biological, Radiological and Nuclear (CBRN) Hazards Based on Toxicological and Situational Parameters

Applied Sciences
CBRN incidents are characterized by high uncertainty in terms of agent identity, dissemination methods, and situational context. This unpredictability complicates effective and timely response, especially in the initial phase before specialist services ...
Leslaw Gorniak, Natalia Cichon, Maksymilian Stela, Marcin Niemcewicz, Marcin Podogrocki, Adrian Siadkowski, Michal Ceremuga, Michal Bijak   +7 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

A new intergovernmental science-policy panel on chemicals, waste and pollution (ISP-CWP)-presenting a conceptual structure for its interdisciplinary expert committee including multidisciplinary civil society scientists

Frontiers in Environmental Science
This perspectives article explores the inception, structure, functions, and anticipated impacts of the new Intergovernmental Science-Policy Panel on Chemicals, Waste and Pollution (ISP-CWP), established in Punta del Este, Uruguay on 20 June 2025. We look
Camilla Alexander-White, Tom Welton
doaj   +1 more source