Results 181 to 190 of about 815,809 (265)

Environmental endocrine disruptors in cardio-oncology: emerging modifiers of cardiovascular vulnerability in patients with cancer. [PDF]

Cardiooncology
Quagliariello V, Berretta M, D'Aiuto G, Bisceglia I, Barbato M, Del Toro B, Santagata J, Canale ML, Paccone A, Inno A, D'Ambrosio C, Oliva S, Dessalvi CC, Di Matola T, Gabrielli D, Fabiani I, Pagliani L, Iliescu CA, Borowiec A, Maurea N.   +19 more
europepmc   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Environmentally Safe and Just Pharmacy: A Framework and Action Plan for Operating within the Earth System Boundary for Novel Entities. [PDF]

Environ Sci Technol
Boxall ABA, Amerasinghe P, Beckenham S, Bertram MG, Gaw S, Gray AD, Kidd KA, Langan LM, Leung KMY, Manera JL, Miglioranza KSB, Oldenkamp R, Brooks BW.   +12 more
europepmc   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

AuLCA: augmented life cycle assessment for chemical data gaps.

Green Chem
Hoepfner MG, Jakobs D, Santos LF, Guillén-Gosálbez G.   +3 more
europepmc   +1 more source

An Exploration of Machine Learning Methods in Human Biomonitoring. [PDF]

Int J Environ Res Public Health
Singh K, Bi J, Musende M, Collins SP, Borghese MM, Hu JMY, Pollock T, St-Amand A, Hennessy D, Buckeridge DL.   +9 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Can Benchmarking Increase the Accuracy of Predicting Biodegradation Rates across Aquatic Ecosystems? [PDF]

Environ Sci Technol
Tian R, Weir LM, Posselt M, Fenner K, McLachlan MS.   +4 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Early Pregnancy Targeted Exposome: Biological Response and Maternal BMI. [PDF]

Toxics
Saadat N, Thangaraj SV, Chovatiya J, Jagani R, Andra SS, Padmanabhan V.   +5 more
europepmc   +1 more source