Results 71 to 80 of about 815,809 (265)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Dumping in the Global Dixie: Circle of Poison and the Contamination of the Global South

open access: yesGlobal Environment
The 1981 publication of David Weir and Mark Shapiro’s exposé Circle of Poison almost ten years after the banning of DDT represented how the landscape of understandings about hazardous chemicals and their regulation had changed.
Amy M. Hay
doaj   +1 more source

Adaptation ukrainian legislation on regulation of manufacture and use of chemicals with EU norms on the basis of partnership and cooperation agreement 1994.

open access: yesТеорія і практика правознавства, 2016
The EU countries have realised necessity of a legal regulation of the chemical substances for health protection of the person and maintenance of natural balance.
О. С. Бабенко
doaj   +1 more source

Biophysical approaches for studying viral entry

open access: yesFEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Legal issues of improving environmental legislation in the field of chemical safety

open access: yesХабаршы. Заң сериясы, 2017
Decisive steps to transform social relations are a complex process that requires thorough study and deep theoretical understanding of representatives of various scientific fields, including lawyers.
Askarova A.O., Suleimenova S.Zh.
doaj  

Long-term analysis of drinking water quality in poultry and pig farms in Northwest Germany

open access: yesFrontiers in Animal Science
Hygienically safe drinking water is essential for the health, well-being, and efficient production of livestock. In contrast to drinking water for human consumption, there are guidelines but no legal limits for drinking water for animals.
Pia Münster, Nicole Kemper
doaj   +1 more source

A pre-validation trial - testing genotoxicity of several chemicals using standard, medium- and high-throughput comet formats.

open access: yesFrontiers in Genetics, 2015
As part of the EU-project COMICS, high throughput versions of the comet assay was developed. In order to test the performance of the new formats; the novel 12-gel slide and the 96-minigel film were compared with standard 3-gel slides for their ability to
Kristine Bjerve Gutzkow   +6 more
doaj   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Chemical Contaminants Associated with Palm Wine from Nigeria Are Potential Food Safety Hazards

open access: yesBeverages, 2017
Recent analysis of palm wine, a traditional drink fermented mainly by yeasts, revealed the presence of several chemicals that were not products of yeast fermentation. The chemicals included styrene, benzene, trimethyldioxolane, dichloromethane, methylene
Ogueri Nwaiwu, Martin Itumoh
doaj   +1 more source

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