Results 111 to 120 of about 8,165,004 (306)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

GENERAL AND PHYSICAL CHEMISTRY.

Journal of the American Chemical Society, 1899
n ...
openaire   +3 more sources

Oxygen vacancy enhanced photocatalytic activity of Cu2O/TiO2 heterojunction

iScience
Summary: In this study, a method was developed to create oxygen vacancies in Cu2O/TiO2 heterojunctions. By varying the amounts of ethylenediaminetetraacetic acid (EDTA), sodium citrate, and copper acetate, Cu2O/TiO2 with different Cu ratios were ...
Hong Qian, Binxia Yuan, Yuhao Liu, Rui Zhu, Weiling Luan, Chengxi Zhang   +5 more
doaj   +1 more source

Synthesis and surface characterization of new triplex polymer of Ag(I) and mixture nucleosides: cytidine and 8-bromoguanosine

Heliyon, 2019
In this work one-dimensional (1D) triplex polymer of silver (I): mixture nucleosides of cytidine and 8-bromoguanosine was synthesised. The polymer showed high stability due to the presence Ag(I) ions in the structure of the polymer in addition to the ...
Lamia L.G. Al-mahamad
doaj   +1 more source

Structural instability of shell-like assemblies of a keplerate-type polyoxometalate induced by ionic strength [PDF]

, 2009
We demonstrate a new structural instability of shell-like assemblies of polyoxometalates. Besides the colloidal instability, that is, the formation of aggregates that consist of many single layered POM-shells, these systems also display an instability on
Physical and Colloid Chemistry, Veen, S.J., Kegel, W.K., Sub Physical and Colloid Chemistry   +3 more
core  

Clay goes patchy [PDF]

, 2011
Empty liquids and equilibrium gels have so far been only theoretical possibilities, predicted for colloids with patchy interactions.
Physical and Colloid Chemistry, Kegel, W.K., Lekkerkerker, H.N.W., Sub Algemeen Scheikunde, Sub Physical and Colloid Chemistry   +4 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Scenario for equilibrium solid-stabilized emulsions [PDF]

, 2009
We show theoretically that under certain conditions colloidal particles can give rise to spontaneous emulsification of oil/water systems. The capillary penalty to create a large interface is compensated by entropic contributions connected to ionic ...
Physical and Colloid Chemistry, Kegel, W.K., Sub Physical and Colloid Chemistry, Groenewold, J.   +3 more
core  

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source