Results 51 to 60 of about 548 (126)

Benthic contributions to the chemical seascape: Insights from Mediterranean underwater caves

Limnology and Oceanography, Volume 71, Issue 6, June 2026.
Abstract Chemical mediation plays a major role in the functioning of marine ecosystems, yet most of the molecules sustaining species interactions remain largely unknown. As an initial step toward clarifying these processes, this study investigates how benthic biodiversity shapes the chemical composition of seawater, using underwater caves as model ...
Marie Derrien, Pierre Chevaldonné, Charlotte Simmler, Thierry Pérez   +3 more
wiley   +1 more source

Progress in Natural Products Target Discovery Technology

MedComm, Volume 7, Issue 6, June 2026.
Here, we provide a comprehensive overview of current technologies and recent advancements in therapeutic target discovery for natural products. By systematically synthesizing the principles, methodologies, and practical applications of existing experimental and computational strategies, this work provides a more actionable reference framework for ...
Qiyuan Pan, Xiao Yuan, Jinmei Jin, Xin Luan, Cheng Luo, Hongzhuan Chen, Weidong Zhang, Hao Zhang   +7 more
wiley   +1 more source

Evaluation of Photophysical Properties and Biological Applications of Diarylmethanes

ChemistryOpen, Volume 15, Issue 6, June 2026.
The wide applications of diarylmethanes were investigated through various experimental and computational approaches. The solvent environment influences the electronic properties of diarylmethanes and hence their drug‐like properties. Interactions with PARP1 revealed stable binding supporting anticancer potential.
H. Ranjini Jenifer, Fateh V. Singh, M. M. Balamurali   +2 more
wiley   +1 more source

In silico identification of potential HDAC3 inhibitors through machine learning, molecular docking, and molecular dynamics simulations for drug repurposing

Aspects of Molecular Medicine
Background: Histone Deacetylase 3 (HDAC3) is an epigenetic enzyme that controls cell cycle progression, apoptosis, and gene expression. Overexpression of HDAC3 has been shown to be a potential contributing factor to the development and spread of breast ...
Damilare P. Dosunmu, Rachael Oluwakamiye Abolade, Mujeebat Bashiru, Adedoyin John-Joy Owolade, Muyiwa Kolawole Samuel, Ebunoluwa Omorilewa Boluwatife, Ayomadewa Mercy Olatunya, Precious O. Aribisala, Samuel Aduramurewa Osunnaya, Micheal Abimbola Oladosu, Ebenezer Ayomide Oni, Damilola Samuel Bodun   +11 more
doaj   +1 more source

Plant‐Derived Treatments for Monogenean Parasites in Farmed Fish: A Systematic Review and Meta‐Analysis

Reviews in Aquaculture, Volume 18, Issue 3, June 2026.
ABSTRACT Monogeneans are among the most problematic ectoparasites in finfish aquaculture. Plant‐derived compounds have been widely explored as therapeutic agents, yet their efficacy and safety have not been quantitatively synthesized across studies. This study provides a meta‐analysis of plant‐based treatments against monogeneans, integrating 453 in ...
Francisco Neptalí Morales‐Serna
wiley   +1 more source

Bio/chemoinformatics in India: an outlook [PDF]

Briefings in Bioinformatics, 2014
With the advent of significant establishment and development of Internet facilities and computational infrastructure, an overview on bio/chemoinformatics is presented along with its multidisciplinary facts, promises and challenges. The Government of India has paved the way for more profound research in biological field with the use of computational ...
Shipra Gupta, Sonali Chavan, Dileep N. Deobagkar, Deepti D. Deobagkar   +3 more
openaire   +2 more sources

Constellation Plots in KNIME: An Automated Scaffold‐Based Workflow for Interactive Chemical Space Visualization

Molecular Informatics, Volume 45, Issue 5, May 2026.
The interactive, automated scaffold‐based Constellation Plot workflow provides a high‐density visual representation of the chemical space of compound datasets with complex relationships. Chemical space analysis is extensively used in different chemistry areas, ranging from the study of natural products to drug discovery projects.
Carlos D. Ramírez‐Márquez, Edgar López‐López, José L. Medina‐Franco   +2 more
wiley   +1 more source

Fragment Library of Natural Products and Compound Databases for Drug Discovery

Biomolecules, 2020
Natural products and semi-synthetic compounds continue to be a significant source of drug candidates for a broad range of diseases, including coronavirus disease 2019 (COVID-19), which is causing the current pandemic.
Ana L. Chávez-Hernández, Norberto Sánchez-Cruz, José L. Medina-Franco   +2 more
doaj   +1 more source

Extending the Targets for Coronavirus Antivirals Beyond That of Approved Drugs: Insights From Preclinical Research

Microbial Biotechnology, Volume 19, Issue 5, May 2026.
Chemical structure of RIBOTAC inhibitor with metabolic handle binding as nucleotide analogue to SARS‐CoV‐2 RNA dependent RNA polymerase, its linker and the RNase L recruiter which binds RNase L monomers and mediates their dimerization that actives nuclease activity degrading the viral RNA.
Harald Brüssow
wiley   +1 more source

Natural polyphenols for sustainable active, smart, and intelligent food packaging: a structured narrative review

Frontiers in Food Science and Technology
Food packaging offers essential food safety to the consumers. Conventional plastic-based food packaging offers only ordinary physical protection and may sometimes accelerate plastic pollution.
Kunal Dutta, Carola Y. Förster, Olga Yu Orlova, Thomas Dandekar, Ekaterina V. Skorb, Sergey Shityakov, Sergey Shityakov   +6 more
doaj   +1 more source