Results 41 to 50 of about 12,027 (208)
A synergistic strategy to develop photostable and bright dyes with long Stokes shift for nanoscopy
Nature Communications, 2022 Super-resolution microscopy is a powerful tool for cellular studies but requires bright and stable fluorescent probes. Here, the authors report on a strategy to introduce quinoxaline motifs to conventional probes to make them brighter, more photostable ...
Gangwei Jiang +8 more
doaj +1 more source
Real‐Time Biomass Estimation in High‐Density Yeast Fermentations Using Soft Sensor Modeling
Biotechnology and Bioengineering, EarlyView.Accurate biomass measurements, both offline and online, are essential to improve prediction and control in yeast fermentation. This study develops regression‐based predictive models to correlate offline measurements (Dry Cell Weight and OD600 from a spectrophotometer) with online OD860 probe signals to provide accurate real‐time biomass estimations and
Ana G. Del Hierro +3 more
wiley +1 more source
Nature Communications, 2020 Size-selective discrimination is an issue in biosensing. Here, the authors report on a size selective DNA nanocage which excludes agents based on size and protects the probes against degradation, and demonstrate the discrimination between mature and ...
Xiaoyi Fu +8 more
doaj +1 more source
Frontiers in Immunology, 2021 Innate immunity is the first line of host defense against pathogen infection in metazoans. However, the molecular mechanisms of the complex immune regulatory network are not fully understood.
Zhongfan Zheng +17 more
doaj +1 more source
Journal of Research of the National Bureau of Standards, 1988 Standards are central to the achievement and maintenance of accuracy in trace analysis. This fact is well-known and well-accepted in the international analytical chemical community, where "standards" are generally considered to be Standard Reference Materials (SRMs) or Certified Reference Materials (CRMs).
openaire +1 more source
Biotechnology Progress, EarlyView.The application of the transfer learning algorithm successfully allowed the use of a model built on process A for real‐time monitoring of process B. This study shows the improvement obtained with this methodology compared to the direct application of the model.
Adèle Schini +7 more
wiley +1 more source
The development of an anti-cancer peptide M1-21 targeting transcription factor FOXM1
Cell & Bioscience, 2023 Background Transcription factor FOXM1 is a potential target for anti-cancer drug development. An interfering peptide M1-21, targeting FOXM1 and FOXM1-interacting proteins, is developed and its anti-cancer efficacy is evaluated.
Haojie Cheng +9 more
doaj +1 more source
Chemosensors, 2023 Instrument automation, technological advancements and improved computational power made separation science an extremely data-rich approach, requiring the use of statistical and data analysis tools that are able to optimize processes and combine multiple ...
Alessandro Zappi +7 more
doaj +1 more source
Biotechnology Progress, EarlyView.Abstract Monoclonal antibody (mAb) titer monitoring is a key capability during process development and optimization, enabling timely decision making and increasing the speed of development. Raman spectroscopy is a prominent process analytical technology (PAT), but resource‐efficient calibration strategies for the development of transferable models are ...
Alexandra Umprecht +4 more
wiley +1 more source
Engineering an asymmetric rhodamine dye suitable for developing ratiometric fluorescent probe
Smart Molecules, 2023 Fluorescent probes based on rhodamine skeleton are extensively used in biological imaging. However, the construction of ratiometric fluorescent probes based on the rhodamine skeleton without introducing additional fluorophores is still challenging ...
Feiyu Yang +4 more
doaj +1 more source