Results 41 to 50 of about 62,649 (242)
Biotechnology and Bioengineering, EarlyView.ABSTRACT Protein aggregation poses a significant risk to biopharmaceutical product quality, as even minor amounts of oligomeric species can compromise efficacy and safety. Rapid and reliable detection of protein aggregates thus remains a major challenge in biopharmaceutical manufacturing.
Jakob Heyer‐Müller +4 more
wiley +1 more source
A synergistic strategy to develop photostable and bright dyes with long Stokes shift for nanoscopy
Nature Communications, 2022 Super-resolution microscopy is a powerful tool for cellular studies but requires bright and stable fluorescent probes. Here, the authors report on a strategy to introduce quinoxaline motifs to conventional probes to make them brighter, more photostable ...
Gangwei Jiang +8 more
doaj +1 more source
Joint selection of wavenumber regions for midir and raman spectra and variables in pls regression using genetic algorithms [PDF]
, 2012 This work fits into the context of cassava processing. Production and consumption of this product is steadily increasing worldwide and especially in tropical regions where, after harvest, cassava starch is extracted according to an empirical process ...
Delarbre, Jean-Louis +6 more
core
Raman Spectroscopy–Based Glucose Feed Control Automates Malic Acid Fermentation
Biotechnology and Bioengineering, EarlyView.Raman spectroscopy enables automated, closed‐loop glucose feeding for malic acid production with Ustilago trichophora. Online PLS regression of glucose and malic acid provides input for PID control to maintain 20 g/L glucose. The feed is dynamically adjusted and stopped in response to metabolic demand and product inhibition, demonstrating practical ...
Luca Antonia Grebe +8 more
wiley +1 more source
Biotechnology Progress, EarlyView.The application of the transfer learning algorithm successfully allowed the use of a model built on process A for real‐time monitoring of process B. This study shows the improvement obtained with this methodology compared to the direct application of the model.
Adèle Schini +7 more
wiley +1 more source
The development of an anti-cancer peptide M1-21 targeting transcription factor FOXM1
Cell & Bioscience, 2023 Background Transcription factor FOXM1 is a potential target for anti-cancer drug development. An interfering peptide M1-21, targeting FOXM1 and FOXM1-interacting proteins, is developed and its anti-cancer efficacy is evaluated.
Haojie Cheng +9 more
doaj +1 more source
Process Performance Analysis in Large-Scale Systems Integrating Different Sources of Information
, 2012 Process auditing using historical data can identify causes for poor performance and reveal opportunities to improve process operation. To date, the data used has been limited to process measurements; however other sources hold complementary information ...
Bauer +19 more
core +1 more source
Nonlinear process fault detection and identification using kernel PCA and kernel density estimation [PDF]
, 2016 Kernel principal component analysis (KPCA) is an effective and efficient technique for monitoring nonlinear processes. However, associating it with upper control limits (UCLs) based on the Gaussian distribution can deteriorate its performance.
Cao, Yi, Samuel, Raphael
core +1 more source
Biotechnology Progress, EarlyView.Abstract Monoclonal antibody (mAb) titer monitoring is a key capability during process development and optimization, enabling timely decision making and increasing the speed of development. Raman spectroscopy is a prominent process analytical technology (PAT), but resource‐efficient calibration strategies for the development of transferable models are ...
Alexandra Umprecht +4 more
wiley +1 more source
Nature Communications, 2020 Size-selective discrimination is an issue in biosensing. Here, the authors report on a size selective DNA nanocage which excludes agents based on size and protects the probes against degradation, and demonstrate the discrimination between mature and ...
Xiaoyi Fu +8 more
doaj +1 more source