Results 221 to 230 of about 70,358 (244)
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Current Problems in Cancer, 1994
Chemoprevention is a strategy used to block the development of cancers in human beings. This emerging field has broad potential for influencing cancer incidence rates in defined high-risk groups and the general population. In this review, we define some of the mechanisms of carcinogenesis, describe some of the genetic markers of carcinogenesis, and ...
C E, Szarka, G, Grana, P F, Engstrom
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Chemoprevention is a strategy used to block the development of cancers in human beings. This emerging field has broad potential for influencing cancer incidence rates in defined high-risk groups and the general population. In this review, we define some of the mechanisms of carcinogenesis, describe some of the genetic markers of carcinogenesis, and ...
C E, Szarka, G, Grana, P F, Engstrom
openaire +2 more sources
Prostate Cancer Chemoprevention
Seminars in Oncology, 2013Prostate cancer is a leading cause of morbidity and mortality in men and has significant treatment-associated complications. Prostate cancer chemoprevention has the potential to decrease the morbidity and mortality associated with this disease. Chemoprevention research to date has primarily focused on nutrients and 5 alpha-reductase inhibitors (5ARIs).
Gurdarshan S, Sandhu +3 more
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Chemoprevention by Pyrimethamine
Immunopharmacology and Immunotoxicology, 2005The goal of the current research was to investigate the chemopreventive potency of an antimalaria drug, pyrimethamine, in in vitro conditions. The fibrosarcoma (WEHI-164) cell line was used for evaluating cytotoxicity, matrix metalloproteinase 2 (MMP-2) activity, and apoptosis. Pyrimethamine and methotrexate were used at concentrations of 0-8 microg/ml
Farshid, Saadat +2 more
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Chemoprevention clinical trials
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1992As part of a program to develop drugs which will delay or prevent cancer in humans, the Chemoprevention Branch, National Cancer Institute, National Institutes of Health, is sponsoring 12 Phase I and 22 Phase II and III clinical trials. Three agent classes are significantly advanced in the trials. These are the retinoids, including 13-cis-retinoic acid,
G J, Kelloff +3 more
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