Results 351 to 360 of about 149,400 (379)
USP9X integrates TGF-β and hypoxia signalings to promote ovarian cancer chemoresistance via HIF-2α-maintained stemness. [PDF]
Cell Death DisZhang Z +11 more
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Hyptolide induces ER stress-mediated cell death and enhances GSK3β-regulated cisplatin chemosensitivity in ovarian cancer. [PDF]
J Ovarian ResRahmania YL +7 more
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Targeting Src reactivates pyroptosis to reverse chemoresistance in lung and pancreatic cancer models
Science Translational Medicine, 2023Pancreatic and lung cancers frequently develop resistance to chemotherapy-induced cell apoptosis during the treatment, indicating that targeting nonapoptotic-related pathways, such as pyroptosis, can be an alternative cancer treatment strategy ...
Liangping Su +13 more
semanticscholar +1 more source
Molecular and Cellular Biochemistry, 2008
Despite improved knowledge and advanced treatments of gliomas, the overall survival rate for glioma patients remains low. Gliomas comprise of significant cell heterogeneity that contains a large number of multidrug resistant (MDR) phenotypes and cancer stem cells (CSCs), a combination that may contribute to the resistance to treatment.
Amal Shervington, Chen Lu
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Despite improved knowledge and advanced treatments of gliomas, the overall survival rate for glioma patients remains low. Gliomas comprise of significant cell heterogeneity that contains a large number of multidrug resistant (MDR) phenotypes and cancer stem cells (CSCs), a combination that may contribute to the resistance to treatment.
Amal Shervington, Chen Lu
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Extracellular Vesicles in Chemoresistance
2021Chemotherapy represents the current mainstay therapeutic approach for most types of cancer. Despite the development of targeted chemotherapeutic strategies, the efficacy of anti-cancer drugs is severely limited by the development of drug resistance. Multidrug resistance (MDR) consists of the simultaneous resistance to various unrelated cytotoxic drugs ...
Mary Bebawy, Gabriele De Rubis
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Chemoresistance in falciparum malaria
Trends in Parasitology, 2003Tropical countries increasingly face the burden of drug resistance in Plasmodium falciparum infections. Malaria-related mortality of African children rises in contrast to the decline of the overall mortality of children under five years of age in sub-Saharan Africa within the past four decades.
Jürgen May, Christian Meyer
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2013
Glioma remains one of the most aggressive and lethal form of cancer. Despite the best available treatment options including surgical resection, radiotherapy, and chemotherapy, prognosis is poor with a median overall survival of just over 1 year. Most patients would die of tumour recurrences because of their tumours’ intrinsic or acquired resistance ...
Sun, S, Leung, GKK, Lee, D
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Glioma remains one of the most aggressive and lethal form of cancer. Despite the best available treatment options including surgical resection, radiotherapy, and chemotherapy, prognosis is poor with a median overall survival of just over 1 year. Most patients would die of tumour recurrences because of their tumours’ intrinsic or acquired resistance ...
Sun, S, Leung, GKK, Lee, D
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Mitochondrial dysfunction in cancer chemoresistance
Biochemical Pharmacology, 2014Mitochondrial dysfunction has been associated with cancer development and progression. Recent evidences suggest that pathogenic mutations or depletion of the mitochondrial genome can contribute to development of chemoresistance in malignant tumors. In this review we will describe the current knowledge on the role of mitochondrial dysfunction in the ...
Guaragnella N, Giannattasio S, Moro L
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