Results 171 to 180 of about 2,687,367 (305)

Potent Antisickling Furaldehyde Analogs for Acute Sickle Cell Therapy: Enhanced Efficacy and Intravenous Formulation Potential

ChemMedChem, EarlyView.
This study reports novel 5‐HMF analogs with potent antisickling activities. Lead compound MMA509 enhances hemoglobin oxygen affinity and prevents erythrocyte sickling. Crystal structure of hemoglobin‐MMA509 complex explains MMA509 mechanism of action. An IV formulation is successfully developed, positioning MMA509 as a promising fast‐acting treatment ...
Abdelsattar M. Omar, Moustafa E. El‐Araby, Tarek A. Ahmed, Akua K. Donkor, Albert Opare, Mohini S. Ghatge, Anfal S. Aljahdali, Rana T. Alhashimi, Trevohn N. Robinson, Benita Balogun, Mariana Macias, Salma Roland, Yan Zhang, Faik N. Musayev, Osheiza Abdulmalik, Martin K. Safo   +15 more
wiley   +1 more source

Cardiac Pseudomyogenic Hemangioendothelioma Presenting as Chest Pain in a Young Athlete. [PDF]

JACC Case Rep
Santolia CB, Miranda LC, Sales Y, Gomes G, Monnerat Magalhaes GC, Mikaloski Penedo RL, Rego Dos Santos M, Alvarez Perez MC, Anderson WJ, Castro Issa F.   +9 more
europepmc   +1 more source

Safety, Pharmacokinetics, and Pharmacodynamics of Osivelotor for Sickle Cell Disease: First‐in‐Human Studies in Healthy Participants and Patients

Clinical Pharmacology &Therapeutics, EarlyView.
The investigational agent osivelotor, a small molecule hemoglobin (Hb) modifier in development for the treatment of sickle cell disease (SCD), acts by increasing Hb‐oxygen affinity and inhibiting the polymerization of sickle Hb. We report safety, pharmacokinetic (PK), and pharmacodynamic (PD) data from the first two phase 1 clinical trials of ...
Eleanor A. Lisbon, R. Clark Brown, Andrew Redfern, Ken Duchin, Aline Barth, Erika S. Roberts, Polo Gaputan, Kobina Dufu, Arthur Lo, Mira Patel Pochron, David R. Archer, Wai Chin, Karena Kong, Carla B. Washington, Adeyemi Adenola, Eric I. Zimmerman   +15 more
wiley   +1 more source

Man With Chest Pain and Unilateral Weakness. [PDF]

J Am Coll Emerg Physicians Open
Ryan H, Hartrich M, Eilbert W.
europepmc   +1 more source

Frequency of chest pain in primary care, diagnostic tests performed and final diagnoses

Heart, 2017
Beatrijs B N Hoorweg, R. Willemsen, Lotte E Cleef, Tom Boogaerts, F. Buntinx, Jan FC Glatz, G. Dinant   +6 more
semanticscholar   +1 more source

Nonsteroidal Anti‐Inflammatory Drugs and Risk of Gastrointestinal Bleeding: A Systematic Review and Meta‐Analysis

Clinical Pharmacology &Therapeutics, EarlyView.
Nonsteroidal anti‐inflammatory drugs (NSAIDs) are widely used for pain and inflammation but are associated with gastrointestinal (GI) bleeding. While this risk is well established, most studies evaluate NSAIDs as a homogenous class, limiting clinical decision‐making based on individual agent safety.
Abdelrahman G. Tawfik, Ainhoa Gomez‐Lumbreras, Guilherme Del Fiol, Kensaku Kawamoto, Katy E. Trinkley, Thomas Reese, Aubrey Jones, Daniel C. Malone   +7 more
wiley   +1 more source

Representation of Older Adults and Women in Randomized Trials of Noninvasive Imaging for Chest Pain. [PDF]

Circ Cardiovasc Imaging
Lim P, Eris T, Shaw LJ, Gelfman L, Gelijns A, Moskowitz A, Bagiella E, Lin FA, Bhatt DL, Stone G, Morrison RS, Cohen D, Nanna M, Alexander K, Patel KK.   +14 more
europepmc   +1 more source

Identification of Patients With Stable Chest Pain Deriving Minimal Value From Noninvasive Testing: The PROMISE Minimal-Risk Tool, A Secondary Analysis of a Randomized Clinical Trial

JAMA cardiology, 2017
C. Fordyce, P. Douglas, R. Roberts, U. Hoffmann, H. Al-Khalidi, M. Patel, C. Granger, J. Kostis, D. Mark, Kerry L Lee, J. Udelson   +10 more
semanticscholar   +1 more source

Forecasting heart failure: Seasonal alignment of heart failure outcomes in New York

ESC Heart Failure, Volume 12, Issue 2, Page 819-831, April 2025.
Abstract Background Seasonal variations have been observed in heart failure (HF) hospitalization. Numerous explanatory mechanisms have been proposed, but no prior studies have examined potential contributors directly. Our objective was to identify specific factors that could contribute to seasonal variability using a large longitudinal dataset of HF ...
Prerna Gupta, Ellen Brinza, Prateeti Khazanie, Pamela N. Peterson, P Michael Ho, David P. Kao   +5 more
wiley   +1 more source

Improvement in Chest Pain Following Surgical Treatment for Thoracic Outlet Syndrome. [PDF]

Ann Vasc Dis
Makita S, Suzuki T, Kiyota Y, Matsumura N, Iwamoto T, Nakamura M.   +5 more
europepmc   +1 more source