Results 91 to 100 of about 2,544 (249)

GPR124 Alleviates Blood–Brain Barrier Disruption by Enhancing Microvascular Endothelial Function after Traumatic Brain Injury

Advanced Science, EarlyView.
Our study reveals the protective role of GPR124 in maintaining BBB integrity and promoting neurological recovery following TBI. It makes a significant contribution by uncovering a novel molecular interaction between GPR124 and FGFBP1 and linking this to activation of the Wnt/β‐catenin signaling pathway in vascular repair mechanisms.
Chen Wang, Lin Cai, Qiuyuan Gong, Yang Yang, Yuqing Liang, Xinyu Niu, Lai Wei, Ze Liu, Shengju Wu, Yinghui Men, Yaohui Tang, Jun Ding, Hengli Tian, Hao Chen   +13 more
wiley   +1 more source

Chewable Tablets: A Comprehensive Review

Asian Journal of Pharmaceutical Research and Development
Tablets that can be chewed between the teeth must be broken before consumption. These tablets are provided to individuals who like swallowing and to youngsters who have difficulty swallowing. These tablets are designed to dissolve smoothly and quickly in the mouth, either with or without chewing.
null Swapnil Sandip Shingade, null Trushali A. Mandhare, null Pooja S. Kashid, Kishor Otari   +3 more
openaire   +1 more source

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

Advanced Science, EarlyView.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu, Bingwei Wang, Zhijie Su, Xiaoxv Han, Miao He, Yun Zhao, Yujia Hou, Daotong Li, Weiguang Zhang, Lihua Qin, Ke Wang, Yanchun Li, Yi Yan, Siwang Yu, Xiaoshuai Huang, Tairan Yuwen, Jianyuan Luo, Ruimao Zheng   +17 more
wiley   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

Efficacy of fluralaner chewable tablets (Bravecto^®) against Asian longhorned tick (Haemaphysalis longicornis) infestations of dogs. [PDF]

Parasit Vectors, 2023
Petersen M, Maree R, Viljoen A, Liebenberg JE, Guerino F.   +4 more
europepmc   +1 more source

Formulation and Evaluation of Ceftazidime Chewable Tablets

International Journal For Multidisciplinary Research
Antimicrobial agents are among the most commonly used and misused of all drugs. The inevitable consequence of the widespread use of antimicrobial agents has been the emergence of antibiotic-resistant pathogens, feeling an ever-increasing need for new drugs.
Shalini Sharma -, Deovrat kumar -
openaire   +1 more source

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source

Clinical evaluation of the efficacy of orocheck tablets as an adjunct to non-surgical periodontal therapy in patients with mild to moderate periodontitis: A randomized controlled clinical trial

Journal of Dr. NTR University of Health Sciences
Aim: The study aims to evaluate the efficacy of probiotic chewable tablets (orocheck) containing Lactobacillus paracasei GMNL-33 along with non-surgical periodontal therapy on clinical parameters of mild to moderate chronic periodontitis (CP) patients ...
Pabbineedi Sai Satya Sri, Dalli Bharath Simha Reddy, Nalamati Shiva Keerthi, Maddula Y S L N V Amruthavalli, Gathram Prathyusha, Kalluri Yasasvi   +5 more
doaj   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Development, optimization, and characterization of vitamin C-fortified oleogel-based chewable gels and a novel nondestructive analysis method for the vitamin C assay

Food Production, Processing and Nutrition
Chewable gels represent an excellent alternative to oral dosage forms, such as tablets and capsules, owing to their appealing appearance, easy swallowing, and attractive colors.
Reyhaneh Sabourian, Farid Abedin Dorkoosh, Mohammad Reza Khoshayand, Mohsen Amini, Zahra Tamiji, Jahan B. Ghasemi, Naficeh Sadeghi, Mannan Hajimahmoodi   +7 more
doaj   +1 more source