Results 41 to 50 of about 291,613 (253)

An Asymptotic Two-Sided Test in a Family of Multivariate Distribution

Journal of Statistical Theory and Applications (JSTA), 2020
In the present paper, a two-sided test in a family of multivariate distribution according to the Mahalanobis distance with mean vector and positive definite matrix is considered.
Abouzar Bazyari, Mahmoud Afshari, Monjed H. Samuh   +2 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Human factor analysis of general accidents in coal mines based on HFACS

Meikuang Anquan, 2021
In order to find out the human factors leading to coal mine general accidents, the paper counts the coal mine accidents occurred in 2019. Based on the investigation reports, HFACS is used to carry out the statistics and analysis of 43 coal mine general ...
BAI Yanlong, LI Haili, CHEN Yu, HE Shulei, BAI Changjiang, XI Long, XUE Yubi, PENG Jiajia, WANG Xin
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

A Socioecological Assessment of Vulture Abundance and Community Perceptions Before and After Landfill Site Shift in Pokhara, Nepal

Ecology and Evolution
South Asia is home to nine species of vultures, and Nepal hosts all of them. Remarkably, all these species have also been recorded in Pokhara. This could be attributed to Pokhara's location along bird migration pathways and the year‐round availability of
Binita Timilsina, Mohan Bucha Magar, Sangam Poudel, Dinesh Bhusal, Dipa Gurung, Ankit Bilash Joshi, Yajna Prasad Timilsina   +6 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Mixed model with spatial variance–covariance structure for accommodating of local stationary trend and its influence on multi-environmental crop variety trial assessment

Spanish Journal of Agricultural Research, 2014
The most common procedure for analyzing multi-environmental trials is based on the assumption that the residual error variance is homogenous across all locations considered.
Asnake Worku Negash, Henry Mwambi, Temesgen Zewotir, Girma Aweke   +3 more
doaj   +1 more source