Results 81 to 90 of about 307,340 (255)

Comparison of the Predictive Values of Multiple Binary Diagnostic Tests in the Presence of Ignorable Missing Data

Revstat Statistical Journal, 2017
The comparison of the predictive values of binary diagnostic tests is an important topic in the study of statistical methods applied to medical diagnosis. In this article, we study a global hypothesis test to simultaneously compare the predictive values
Ana Eugenia Marín-Jimenéz, José Antonio Roldán-Nofuentes   +1 more
doaj   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Sustainable Development of Innovation Hubs in the Indian Green Building Sector

Baltic Journal of Real Estate Economics and Construction Management
This research aims to analyse the factors influencing the sustainable development of innovation hubs in the Indian green building sector. The research focuses on the significance of innovation hubs in enhancing sustainability in the Indian green building
Mukund Nimisha, Vijayakumar Anandhu, Davidova Jelena   +2 more
doaj   +1 more source

Factors Influencing Flight Delays of a European Airline

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2017
The main aim of the paper was to investigate factors influencing flight delays of a European airline. Besides the identification and analysis of those factors the paper offers possible suggestions on how to eliminate the delays.
Martina Zámková, Martin Prokop, Radek Stolín   +2 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Analysis of the Impact of a Passive Interest in Sport on Student Lifestyle

Ekonometria
Aim: The aim of the study was to determine the impact of a passive interest in sport on student lifestyle. Particular attention was given to analysing the relationship between the consumption of sports-related content and health behaviour, as well as ...
Dominik Głowacki
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

The asymptotic distribution of the likelihood ratio test statistic in two-peak discovery experiments

European Physical Journal C: Particles and Fields
Likelihood ratio tests are widely used in high-energy physics, where the test statistic is usually assumed to follow a chi-squared distribution with a number of degrees of freedom specified by Wilks’ theorem.
Clara Bertinelli Salucci, Hedvig Borgen Reiersrud, A. L. Read, Anders Kvellestad, Riccardo De Bin   +4 more
doaj   +1 more source