Results 51 to 60 of about 47,626 (168)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Statistical Homogeneity Zoning of a High and Steep Slope Based on Chi-Square Test

Chemical Engineering Transactions, 2018
This paper aims to develop an objective and rational method for statistical homogeneity zoning of high and steep slopes. For this purpose, the fracture trace length was introduced to the statistical homogeneity zoning based on the statistical similarity ...
Ming Li, Shuochao Bao, Huiming Liu
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Relationship between Chinese medicine dietary patterns and the incidence of breast cancer in Chinese women in Hong Kong: a retrospective cross-sectional survey

Chinese Medicine, 2017
Background This retrospective cross-sectional study aimed to investigate the relationship between Chinese medicine (CM) dietary patterns (hot, neutral, and cold) and the incidence of breast cancer among Chinese women in Hong Kong.
Xiao Zheng, Jianping Chen, Ting Xie, Zhiyu Xia, Wings Tjing Yung Loo, Lixing Lao, JieShu You, Jie Yang, Kamchuen Tsui, Feizhi Mo, Fei Gao   +10 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Statistical insights from Romanian data on higher education [PDF]

Revista Română de Statistică, 2015
This paper aims to use cluster analysis to make a comparative analysis at regional level concerning the Romanian higher education. The evolution of higher education in post-communist period will also be presented, using quantitative traits.
Andreea Ardelean
doaj  

Analysis of Paired Dichotomous Data: A Gentle Introduction to the McNemar Test in SPSS

Journal of MultiDisciplinary Evaluation, 2012
Background: Although McNemar Test is the most appropriate tool for analyzing pre-post differences in dichotomous items (e.g., “yes” or “no”, “correct” or “incorrect”, etc.), many scholars have noted the inappropriate use of Pearson’s Chi-square Test by ...
Omolola A. Adedokun, Wilella D. Burgess
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

NMR Thermal Control Subsystem Reliability Design and Verification Based on Chi-Square Test

Zhongguo yiliao qixie zazhi
The nuclear magnetic resonance (NMR) thermal control subsystem described in this paper is a newly developed platform-based thermal management solution. It presents critical challenges in system architecture design and core component selection. Therefore,
Tingwei LIU, Cunli ZHANG, Jie ZHOU, Gang HU   +3 more
doaj   +1 more source