Results 41 to 50 of about 9,650,040 (289)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Law School Record, vol. 45, no. 1 (Fall 1998) [PDF]
, 1998 A Message from the Dean: Looking Forward The Chicago Norms Reminiscences and Ruminations about the Law School The Law School Names Its Eleventh Dean: Daniel R. Fischel \u2777 Law School News In Memoriamhttps://chicagounbound.uchicago.edu/lawschoolrecord/
Law School Record Editors
core +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Law School Record, vol. 48, no. 1 (Fall 2001) [PDF]
, 2001 Chicago Plans - Dean Levmore\u27s Ideas Career Projections Student Life Alumni News Law School Lifehttps://chicagounbound.uchicago.edu/lawschoolrecord/1084/thumbnail ...
Law School Record Editors
core +1 more source
Law School Record, vol. 60, no. 1 (Fall 2013) [PDF]
, 2013 The Big Impact of “Soft Skills” Law School Graduates Lead in Multiple Fields On Teaching Leadership Madam Chief Judge University of Chicago Law School Graduation 2013 A Champion for Womenhttps://chicagounbound.uchicago.edu/lawschoolrecord/1117/thumbnail ...
Editors, Law School Record
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Forum SociológicoThis paper uses Brecht’s stage play Saint Joan of the Stockyards as scenery to critically analyze the Chicago School’s approach towards human ecology which primarily targeted the environmental and temporal circumstances of human existence and engaged in ...
Hans Eickhoff
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source